6-[[6-(1-甲基-1H-吡唑-4-基)咪唑并[1,2-B]哒嗪-3-基]甲基]喹啉

• 常用名: 6-[[6-(1-甲基-1H-吡唑-4-基)咪唑并[1,2-B]哒嗪-3-基]甲基]喹啉
• 英文名: NVP-BVU972
• CAS号: 1185763-69-2
• 分子量: 340.381
• 密度: 1.4±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₀H₁₆N₆
• 熔点: N/A
• 闪点: N/A

用途

NVP-BVU972是高活性Met抑制剂,IC50为14 nM,对其它的激酶抑制性较低。

名称

• 中文名: 6-[[6-(1-甲基-1H-吡唑-4-基)咪唑并[1,2-B]哒嗪-3-基]甲基]喹啉
• 英文名: 6-[[6-(1-methylpyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl]quinoline

生物活性

• 描述: NVP-BVU972是高活性Met抑制剂,IC50为14 nM,对其它的激酶抑制性较低。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> c-Met的/HGFR
  研究领域 >> 癌症
• 参考文献:

  [1]. Tiedt, Ralph, et al. A Drug Resistance Screen Using a Selective MET Inhibitor Reveals a Spectrum of Mutations That Partially Overlap with Activating Mutations Found in Cancer Patients. Cancer Research (2011), 71(15), 5255-5264.

  [2]. Shin JS, et al. NPS-1034, a novel MET inhibitor, inhibits the activated MET receptor and its constitutively active mutants. Invest New Drugs. 2013 Oct 31.

物理化学性质

• 密度: 1.4±0.1 g/cm3
• 分子式: C₂₀H₁₆N₆
• 分子量: 340.381
• 精确质量: 340.143646
• PSA: 60.90000
• LogP: 2.12
• InChIKey: RNCNPRCUHHDYPC-UHFFFAOYSA-N
• SMILES: Cn1cc(-c2ccc3ncc(Cc4ccc5ncccc5c4)n3n2)cn1
• 外观性状: 粉末
• 折射率: 1.745
• 储存条件: -20℃

安全信息

• 危害码 (欧洲): N

靶点实验

查看更多实验

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Primary qHTS for Identification of Small Molecule Activators of Huntingtin-Antisense ... 来源：NCGC External Id：huntington-HTTAS8-p1-FF-overN

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Inhibition of c-Met (unknown origin) 来源：ChEMBL 靶标：Hepatocyte growth factor receptor External Id：CHEMBL3767620

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

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英文别名

• BVU972
• cc-601
• CS-0967
• 6-((6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl)methyl)quinoline
• 6-{[6-(1-Methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl}quinoline
• 3qti
• NVPBVU972
• NVP-BVU972