氟曲马唑

• 常用名: 氟曲马唑
• 英文名: FLUTRIMAZOLE
• CAS号: 119006-77-8
• 分子量: 346.373
• 密度: 1.2±0.1 g/cm3
• 沸点: 457.1±40.0 °C at 760 mmHg
• 分子式: C₂₂H₁₆F₂N₂
• 熔点: 161-166ºC
• 闪点: 230.3±27.3 °C

氟曲马唑用途

氟苯三唑是一种咪唑类抗真菌药,具有抗炎和抗真菌双重活性。氟苯三唑经皮渗透性差。氟苯三唑在研究具有炎症成分的局部真菌感染方面具有优势[1]。

氟曲马唑名称

• 中文名: 氟曲马唑
• 英文名: flutrimazole
• 中文别名: 氟曲吗唑 | 1-[(2-氟苯基)(4-氟苯基)(苯基)甲基]咪唑 | 1-[(2-氟苯基)-(4-氟苯基)苯基甲基]-1H-咪唑

氟曲马唑生物活性

• 描述: 氟苯三唑是一种咪唑类抗真菌药,具有抗炎和抗真菌双重活性。氟苯三唑经皮渗透性差。氟苯三唑在研究具有炎症成分的局部真菌感染方面具有优势[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 真菌
• 参考文献:

  [1]. Merlos M, et al. Topical anti-inflammatory properties of flutrimazole, a new imidazole antifungal agent. Inflamm Res. 1996;45(1):20-25.

  [2]. Ramis J, et al. Influence of formulation on the in vitro transdermal penetration of flutrimazole. Arzneimittelforschung. 1997;47(10):1139-1144.

氟曲马唑物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 457.1±40.0 °C at 760 mmHg
• 熔点: 161-166ºC
• 分子式: C₂₂H₁₆F₂N₂
• 分子量: 346.373
• 闪点: 230.3±27.3 °C
• 精确质量: 346.128143
• PSA: 17.82000
• LogP: 4.95
• InChIKey: QHMWCHQXCUNUAK-UHFFFAOYSA-N
• SMILES: Fc1ccc(C(c2ccccc2)(c2ccccc2F)n2ccnc2)cc1
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.590
• 储存条件: 室温，干燥

氟曲马唑毒性和生态

氟曲马唑靶点实验

查看更多实验

实验名称：Compound was evaluated for inhibition of rat Gabra1 in an in vitro assay with cellula... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-1 External Id：CHEMBL5291801

实验名称：Binding affinity towards rat Gabra1 in an in vitro assay with cellular components mea... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-1 External Id：CHEMBL5291798

实验名称：Binding affinity towards human ESR1 in an in vitro cell free assay (NIBR assay) measu... 来源：ChEMBL 靶标：Estrogen receptor External Id：CHEMBL5291791

实验名称：Binding affinity towards human HRH3 in an in vitro assay with cellular components mea... 来源：ChEMBL 靶标：Histamine H3 receptor External Id：CHEMBL5291921

实验名称：The chemical genetic matrix (CGM) dataset as reported in Wildenhain et al. (2015) Pre... 来源：11924 靶标：N/A External Id：CGM data for Cell Systems paper Dec 2015

实验名称：Binding affinity towards human EDNRA in an in vitro assay with cellular components me... 来源：ChEMBL 靶标：Endothelin-1 receptor External Id：CHEMBL5291785

实验名称：Binding affinity towards human DRD2 in an in vitro assay with cellular components mea... 来源：ChEMBL 靶标：D(2) dopamine receptor External Id：CHEMBL5291781

实验名称：Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resol... 来源：ChEMBL 靶标：D(1A) dopamine receptor External Id：CHEMBL5291777

实验名称：Antagonist activity at human CNR1 in an in vitro cell-based assay measured by fluores... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL5291772

实验名称：Binding affinity towards human DRD3 in an in vitro assay with cellular components mea... 来源：ChEMBL 靶标：D(3) dopamine receptor External Id：CHEMBL5291899

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氟曲马唑英文别名

• Flutrimazolum
• 1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-Imidazol
• Flutrimazole (INN)
• FLUTRIMAZOLE
• 1-((2-fluorophenyl)(4-fluorophenyl)phenylmethyl)-1H-imidazole
• Micetal
• Flutrimazolum [INN-Latin]
• Flutrimazol [INN-Spanish]
• 1-[(2-fluorophenyl)-(4-fluorophenyl)-phenylmethyl]imidazole
• MFCD00865591
• Flutrimazol
• 1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole
• 1-[o-Fluoro-a-(p-fluorophenyl)-a-phenylbenzyl]imidazole
• UR-4056