119006-77-8

• 常用中文名：氟曲马唑
• 常用英文名：FLUTRIMAZOLE
• CAS号：119006-77-8
• 分子式：C₂₂H₁₆F₂N₂
• 分子量：346.373
• 相关类别： 分析化学 标准品 药典标准品和杂志标准品
• 发布时间：2018-09-14 06:16:00
• 更新时间：2024-01-10 10:20:12
• 氟苯三唑是一种咪唑类抗真菌药,具有抗炎和抗真菌双重活性。氟苯三唑经皮渗透性差。氟苯三唑在研究具有炎症成分的局部真菌感染方面具有优势[1]。

名称

• 中文名: 氟曲马唑
• 英文名: flutrimazole
• 中文别名: 氟曲吗唑; 1-[(2-氟苯基)(4-氟苯基)(苯基)甲基]咪唑; 1-[(2-氟苯基)-(4-氟苯基)苯基甲基]-1H-咪唑
• 英文别名: Flutrimazolum; 1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-Imidazol; Flutrimazole (INN); FLUTRIMAZOLE; 1-((2-fluorophenyl)(4-fluorophenyl)phenylmethyl)-1H-imidazole; Micetal; Flutrimazolum [INN-Latin]; Flutrimazol [INN-Spanish]; 1-[(2-fluorophenyl)-(4-fluorophenyl)-phenylmethyl]imidazole; MFCD00865591; Flutrimazol; 1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole; 1-[o-Fluoro-a-(p-fluorophenyl)-a-phenylbenzyl]imidazole; 1H-Imidazole, 1-[(2-fluorophenyl)(4-fluorophenyl)phenylmethyl]-; UR-4056

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 457.1±40.0 °C at 760 mmHg
• 熔点: 161-166ºC
• 分子式: C₂₂H₁₆F₂N₂
• 分子量: 346.373
• 闪点: 230.3±27.3 °C
• 精确质量: 346.128143
• PSA: 17.82000
• LogP: 4.95
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.590
• 储存条件: 室温，干燥

生物活性

• 描述: 氟苯三唑是一种咪唑类抗真菌药,具有抗炎和抗真菌双重活性。氟苯三唑经皮渗透性差。氟苯三唑在研究具有炎症成分的局部真菌感染方面具有优势[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 真菌
• 参考文献:

  [1]. Merlos M, et al. Topical anti-inflammatory properties of flutrimazole, a new imidazole antifungal agent. Inflamm Res. 1996;45(1):20-25.

  [2]. Ramis J, et al. Influence of formulation on the in vitro transdermal penetration of flutrimazole. Arzneimittelforschung. 1997;47(10):1139-1144.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NI6259450 CHEMICAL NAME : 1H-Imidazole, 1-((2-fluorophenyl)(4-fluorophenyl)phenylmethyl)- CAS REGISTRY NUMBER : 119006-77-8 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C22-H16-F2-N2 MOLECULAR WEIGHT : 346.40 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 808 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,841,1992 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1079 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,841,1992 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,841,1992 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,841,1992

合成路线

342-24-5 ~% 119006-77-8

文献：Arzneimittel-Forschung/Drug Research, , vol. 42, # 6 p. 832 - 835

128092-72-8 ~% 119006-77-8

文献：Arzneimittel-Forschung/Drug Research, , vol. 42, # 6 p. 832 - 835

460-00-4 ~% 119006-77-8

文献：Arzneimittel-Forschung/Drug Research, , vol. 42, # 6 p. 832 - 835

288-32-4 128092-75-1 ~% 119006-77-8

文献：Arzneimittel-Forschung/Drug Research, , vol. 42, # 6 p. 832 - 835

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