CZC-25146

• 常用名: CZC-25146
• 英文名: CZC 25146
• CAS号: 1191911-26-8
• 分子量: 488.535
• 密度: 1.4±0.1 g/cm3
• 沸点: 697.4±65.0 °C at 760 mmHg
• 分子式: C₂₂H₂₅FN₆O₄S
• 熔点: N/A
• 闪点: 375.5±34.3 °C

CZC-25146用途

CZC-25146是代谢稳定性的LRRK2抑制剂，对野生型LRRK2和G2019S LRRK2的IC50分别为4.76 nM和6.87 nM。

CZC-25146名称

• 中文名: CZC-25146
• 英文名: N-(2-(5-fluoro-2-(2-methoxy-4-morpholinophenylamino)pyrimidin-4-ylamino)phenyl)methanesulfonamide

CZC-25146生物活性

• 描述: CZC-25146是代谢稳定性的LRRK2抑制剂,对野生型LRRK2和G2019S LRRK2的IC50分别为4.76 nM和6.87 nM。
• 相关类别:
  信号通路 >> 自噬 >> LRRK2
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Ramsden N, et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. ACS Chem Biol. 2011 Oct 21;6(10):1021-8.

CZC-25146物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 697.4±65.0 °C at 760 mmHg
• 分子式: C₂₂H₂₅FN₆O₄S
• 分子量: 488.535
• 闪点: 375.5±34.3 °C
• 精确质量: 488.164215
• PSA: 126.09000
• LogP: 1.50
• InChIKey: XXHHOTZUJIXPJX-UHFFFAOYSA-N
• SMILES: COc1cc(N2CCOCC2)ccc1Nc1ncc(F)c(Nc2ccccc2NS(C)(=O)=O)n1
• 蒸汽压: 0.0±2.2 mmHg at 25°C
• 折射率: 1.655
• 储存条件: 2-8℃

CZC-25146靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Inhibition of Plasmodium falciparum PKB assessed as remaining activity at 1 uM incuba... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5393200

实验名称：Inhibition of Plasmodium falciparum PK9 assessed as remaining activity at 1 uM incuba... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5393199

实验名称：Inhibition of LRRK2 G2019S mutant (unknown origin) using biotinylated ezrin/radaxin/m... 来源：ChEMBL 靶标：Leucine-rich repeat serine/threonine-protein kinase 2 External Id：CHEMBL4018178

实验名称：Inhibition of Plasmodium falciparum NEK3 assessed as remaining activity at 1 uM incub... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5393196

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Confirmatory qHTS assay for inhibitors of Glutamate pyruvate transaminase 2 (GPT2) 来源：NCGC External Id：TRND-GPT2-f1-with-DTT

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Inhibition of Plasmodium falciparum ARK3 assessed as remaining activity at 1 uM incub... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5393191

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CZC-25146英文别名

• N-(2-(2-(2-Methoxy-4-morpholinophenylamino)-5-fluoropyrimidin-4-ylamino)phenyl)methanesulfonamide
• N-{2-[(5-Fluoro-2-{[2-methoxy-4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)amino]phenyl}methanesulfonamide
• CZC-25146