CZC-54252

• 常用名: CZC-54252
• 英文名: CZC-54252
• CAS号: 1191911-27-9
• 分子量: 504.990
• 密度: 1.5±0.1 g/cm3
• 沸点: 718.1±70.0 °C at 760 mmHg
• 分子式: C₂₂H₂₅ClN₆O₄S
• 熔点: N/A
• 闪点: 388.1±35.7 °C

CZC-54252用途

CZC-54252是LRRK2高效抑制剂，对野生型LRRK2和突变型G2019S LRRK2的IC50值分别为1.28和1.85nM。

CZC-54252名称

• 中文名: CZC-54252
• 英文名: N-(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)pyrimidin-4-ylamino)phenyl)methanesulfonamide

CZC-54252生物活性

• 描述: CZC-54252是LRRK2高效抑制剂,对野生型LRRK2和突变型G2019S LRRK2的IC50值分别为1.28和1.85nM。
• 相关类别:
  信号通路 >> 自噬 >> LRRK2
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Ramsden N, et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. ACS Chem Biol. 2011 Oct 21;6(10):1021-8.

  [2]. Ramsden N, et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. ACS Chem Biol. 2011 Oct 21;6(10):1021-8.

CZC-54252物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 718.1±70.0 °C at 760 mmHg
• 分子式: C₂₂H₂₅ClN₆O₄S
• 分子量: 504.990
• 闪点: 388.1±35.7 °C
• 精确质量: 504.134644
• PSA: 126.09000
• LogP: 1.67
• InChIKey: CLGWUCNXOBLWFM-UHFFFAOYSA-N
• SMILES: COc1cc(N2CCOCC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1
• 外观性状: white solid
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.667
• 储存条件: -20℃

CZC-54252靶点实验

查看更多实验

实验名称：Inhibition of Plasmodium falciparum NEK3 incubated for 2 hrs by luciferin-reagent bas... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5393203

实验名称：Inhibition of Plasmodium falciparum ARK3 incubated for 2 hrs by luciferin-reagent bas... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5393202

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Inhibition of Plasmodium falciparum ARK1 incubated for 2 hrs by luciferin-reagent bas... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5393201

实验名称：Inhibition of Plasmodium falciparum PKB assessed as remaining activity at 1 uM incuba... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5393200

实验名称：Inhibition of Plasmodium falciparum PK9 assessed as remaining activity at 1 uM incuba... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5393199

实验名称：Inhibition of Plasmodium falciparum PK6 assessed as remaining activity at 1 uM incuba... 来源：ChEMBL 靶标：Cdk-related protein kinase 6 External Id：CHEMBL5393198

实验名称：Inhibition of Plasmodium falciparum PK5 assessed as remaining activity at 1 uM incuba... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5393197

实验名称：Inhibition of Plasmodium falciparum NEK3 assessed as remaining activity at 1 uM incub... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5393196

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

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CZC-54252英文别名

• czc 54252 hydrochloride
• N-{2-[(5-Chloro-2-{[2-methoxy-4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)amino]phenyl}methanesulfonamide
• CZC-54252