Besipirdine

更新时间：2025-08-27 12:58:56

Besipirdine结构式	常用名	Besipirdine	英文名	Besipirdine
	CAS号	119257-34-0	分子量	251.32600
	密度	1.09g/cm3	沸点	405.9ºC at 760 mmHg
	分子式	C₁₆H₁₇N₃	熔点	N/A
	MSDS	N/A	闪点	199.3ºC

Besipirdine用途

贝西平是一种具有去甲肾上腺素活性的非受体依赖性拟胆碱药。贝西平抑制电压依赖性钠和钾通道。

英文名	N-propyl-N-pyridin-4-ylindol-1-amine
英文别名	更多

描述	贝西平是一种具有去甲肾上腺素活性的非受体依赖性拟胆碱药。贝西平抑制电压依赖性钠和钾通道。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体研究领域 >> 神经疾病
参考文献	[1]. Hsu RS, DiLeo EM, Chesson SM, Klein JT, Effland RC. Determination of HP 749, a potential therapeutic agent for Alzheimer's disease, in plasma by high-performance liquid chromatography. J Chromatogr. 1991;572(1-2):352-359. [2]. Tang L, Smith CP, Huger FP, Kongsamut S. Effects of besipirdine at the voltage-dependent sodium channel. Br J Pharmacol. 1995;116(5):2468-2472.

描述

贝西平是一种具有去甲肾上腺素活性的非受体依赖性拟胆碱药。贝西平抑制电压依赖性钠和钾通道。

相关类别

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体

研究领域 >> 神经疾病

参考文献

[1]. Hsu RS, DiLeo EM, Chesson SM, Klein JT, Effland RC. Determination of HP 749, a potential therapeutic agent for Alzheimer's disease, in plasma by high-performance liquid chromatography. J Chromatogr. 1991;572(1-2):352-359.

[2]. Tang L, Smith CP, Huger FP, Kongsamut S. Effects of besipirdine at the voltage-dependent sodium channel. Br J Pharmacol. 1995;116(5):2468-2472.

密度	1.09g/cm3
沸点	405.9ºC at 760 mmHg
分子式	C₁₆H₁₇N₃
分子量	251.32600
闪点	199.3ºC
精确质量	251.14200
PSA	21.06000
LogP	3.71600
InChIKey	OTPPJICEBWOCKD-UHFFFAOYSA-N
SMILES	CCCN(c1ccncc1)n1ccc2ccccc21
蒸汽压	8.49E-07mmHg at 25°C

吲哚

120-72-9

Besipirdine

119257-34-0

文献：Klein; Davis; Olsen; Wong; Huger; Smith; Petko; Cornfeldt; Wilker; Blitzer; Landau; Haroutunian; Martin; Effland Journal of Medicinal Chemistry, 1996 , vol. 39, # 2 p. 570 - 581

1H-吲哚-1-胺

53406-38-5

Besipirdine

119257-34-0

文献：Klein; Davis; Olsen; Wong; Huger; Smith; Petko; Cornfeldt; Wilker; Blitzer; Landau; Haroutunian; Martin; Effland Journal of Medicinal Chemistry, 1996 , vol. 39, # 2 p. 570 - 581

溴代丙烷

106-94-5

N-(吡啶-4-基)-1H-吲哚-1-胺

119257-33-9

Besipirdine

119257-34-0

文献：Klein; Davis; Olsen; Wong; Huger; Smith; Petko; Cornfeldt; Wilker; Blitzer; Landau; Haroutunian; Martin; Effland Journal of Medicinal Chemistry, 1996 , vol. 39, # 2 p. 570 - 581

Besipirdine上游产品 4
CAS号120-72-9 吲哚 CAS号53406-38-5 1H-吲哚-1-胺 CAS号106-94-5 溴代丙烷 CAS号119257-33-9 N-(吡啶-4-基)-1H-吲哚-1-胺
Besipirdine下游产品 0

实验名称：Inhibitory activity against [3H]clonidine binding to Alpha-2 adrenergic receptor in r...
来源：ChEMBL
靶标：Alpha-2A adrenergic receptor
External Id：CHEMBL643915

实验名称：Antagonistic activity against Scopolamine induced behavioral deficits in mice at dose...
来源：ChEMBL
靶标：Mus musculus
External Id：CHEMBL722291

实验名称：Compound was evaluated in vitro in rats for the inhibition of brain (striatal) acetyl...
来源：ChEMBL
靶标：Acetylcholinesterase
External Id：CHEMBL642835

实验名称：Inhibitory activity against norepinephrine (NE) uptake in rat whole brain synaptosome...
来源：ChEMBL
靶标：Sodium-dependent noradrenaline transporter
External Id：CHEMBL806826

实验名称：Effective dose against administration in mice
来源：ChEMBL
靶标：Mus musculus
External Id：CHEMBL721029

实验名称：Antagonistic activity against Scopolamine induced behavioral deficits in mice; 5/6
来源：ChEMBL
靶标：Mus musculus
External Id：CHEMBL718319

实验名称：Evaluated for the prevention of TBZ ptosis by intraperitoneal administration in mice
来源：ChEMBL
靶标：Mus musculus
External Id：CHEMBL717284

实验名称：Inhibitory activity against [3H]WB-4101 binding to Alpha-1 adrenergic receptor in rat...
来源：ChEMBL
靶标：Alpha-1A adrenergic receptor
External Id：CHEMBL643637

实验名称：Antagonistic activity against scopolamine-induced behavioral deficits in mice by subc...
来源：ChEMBL
靶标：Mus musculus
External Id：CHEMBL722847

实验名称：Antagonistic activity against scopolamine-induced behavioral deficits in mice by subc...
来源：ChEMBL
靶标：Mus musculus
External Id：CHEMBL723434

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UNII-95PY16J933

N-(n-propyl)-N-(4-pyridinyl)-1H-indol-1-amine

N-propy-N-(4-pyridinyl)-1H-indol-1-amine

N-propyl-N-(pyridin-4-yl)-N-1H-indolyl-1-amine

1-(propyl-4-pyridylamino)indole

Besipirdine

Besipirdine [INN]

1H-Indol-1-amine,N-propyl-N-4-pyridinyl-,monohydrochloride

N-propyl-N-4-pyridinyl-1H-indol-1-amine