Besipirdine

• 常用名: Besipirdine
• 英文名: Besipirdine
• CAS号: 119257-34-0
• 分子量: 251.32600
• 密度: 1.09g/cm3
• 沸点: 405.9ºC at 760 mmHg
• 分子式: C₁₆H₁₇N₃
• 熔点: N/A
• 闪点: 199.3ºC

Besipirdine用途

贝西平是一种具有去甲肾上腺素活性的非受体依赖性拟胆碱药。贝西平抑制电压依赖性钠和钾通道。

Besipirdine名称

• 英文名: N-propyl-N-pyridin-4-ylindol-1-amine

Besipirdine生物活性

• 描述: 贝西平是一种具有去甲肾上腺素活性的非受体依赖性拟胆碱药。贝西平抑制电压依赖性钠和钾通道。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Hsu RS, DiLeo EM, Chesson SM, Klein JT, Effland RC. Determination of HP 749, a potential therapeutic agent for Alzheimer's disease, in plasma by high-performance liquid chromatography. J Chromatogr. 1991;572(1-2):352-359.

  [2]. Tang L, Smith CP, Huger FP, Kongsamut S. Effects of besipirdine at the voltage-dependent sodium channel. Br J Pharmacol. 1995;116(5):2468-2472.

Besipirdine物理化学性质

• 密度: 1.09g/cm3
• 沸点: 405.9ºC at 760 mmHg
• 分子式: C₁₆H₁₇N₃
• 分子量: 251.32600
• 闪点: 199.3ºC
• 精确质量: 251.14200
• PSA: 21.06000
• LogP: 3.71600
• InChIKey: OTPPJICEBWOCKD-UHFFFAOYSA-N
• SMILES: CCCN(c1ccncc1)n1ccc2ccccc21
• 蒸汽压: 8.49E-07mmHg at 25°C

Besipirdine靶点实验

查看更多实验

实验名称：Inhibitory activity against [3H]clonidine binding to Alpha-2 adrenergic receptor in r... 来源：ChEMBL 靶标：Alpha-2A adrenergic receptor External Id：CHEMBL643915

实验名称：Antagonistic activity against Scopolamine induced behavioral deficits in mice at dose... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL722291

实验名称：Compound was evaluated in vitro in rats for the inhibition of brain (striatal) acetyl... 来源：ChEMBL 靶标：Acetylcholinesterase External Id：CHEMBL642835

实验名称：Inhibitory activity against norepinephrine (NE) uptake in rat whole brain synaptosome... 来源：ChEMBL 靶标：Sodium-dependent noradrenaline transporter External Id：CHEMBL806826

实验名称：Effective dose against administration in mice 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL721029

实验名称：Antagonistic activity against Scopolamine induced behavioral deficits in mice; 5/6 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL718319

实验名称：Evaluated for the prevention of TBZ ptosis by intraperitoneal administration in mice 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL717284

实验名称：Inhibitory activity against [3H]WB-4101 binding to Alpha-1 adrenergic receptor in rat... 来源：ChEMBL 靶标：Alpha-1A adrenergic receptor External Id：CHEMBL643637

实验名称：Antagonistic activity against scopolamine-induced behavioral deficits in mice by subc... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL722847

实验名称：Antagonistic activity against scopolamine-induced behavioral deficits in mice by subc... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL723434

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Besipirdine英文别名

• UNII-95PY16J933
• N-(n-propyl)-N-(4-pyridinyl)-1H-indol-1-amine
• N-propy-N-(4-pyridinyl)-1H-indol-1-amine
• N-propyl-N-(pyridin-4-yl)-N-1H-indolyl-1-amine
• 1-(propyl-4-pyridylamino)indole
• Besipirdine
• Besipirdine [INN]
• 1H-Indol-1-amine,N-propyl-N-4-pyridinyl-,monohydrochloride
• N-propyl-N-4-pyridinyl-1H-indol-1-amine