布格替尼

• 常用名: 布格替尼
• 英文名: AP26113
• CAS号: 1197958-12-5
• 分子量: 529.014
• 密度: 1.3±0.1 g/cm3
• 沸点: 737.6±70.0 °C at 760 mmHg
• 分子式: C₂₆H₃₄ClN₆O₂P
• 熔点: N/A
• 闪点: 399.9±35.7 °C

布格替尼用途

ALK-IN-1是ALK激酶高效选择性抑制剂,出自专利US20140066406 A1。

布格替尼名称

• 中文名: 布格替尼
• 英文名: 5-chloro-2-N-[4-[4-(dimethylamino)piperidin-1-yl]-2-methoxyphenyl]-4-N-(2-dimethylphosphorylphenyl)pyrimidine-2,4-diamine
• 中文别名: 5-氯-N2-[4-[4-(二甲基氨基)-1-哌啶基]-2-甲氧基苯基]-N4-[2-(二甲基亚膦酰)苯基]-2,4-嘧啶二胺

布格替尼生物活性

• 描述: ALK-IN-1是ALK激酶高效选择性抑制剂,出自专利US20140066406 A1。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> ALK
  研究领域 >> 癌症
• 参考文献:

  [1]. Sen Zhang, Frank Wang, Jeffrey Keats, Abstract LB-298: AP26113, a potent ALK inhibitor, overcomes mutations in EML4-ALK that confer resistance to PF-02341066 (PF1066). Cancer Research: April 15, 2010; Volume 70, Issue 8, Supplement 1

  [2]. Victor M. Rivera, Frank Wang, Rana Anjum, Abstract 1794: AP26113 is a dual ALK/EGFR inhibitor: Characterization against EGFR T790M in cell and mouse models of NSCLC. Cancer Research: April 15, 2012; Volume 72, Issue 8, Supplement 1

布格替尼物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 737.6±70.0 °C at 760 mmHg
• 分子式: C₂₆H₃₄ClN₆O₂P
• 分子量: 529.014
• 闪点: 399.9±35.7 °C
• 精确质量: 528.216919
• PSA: 95.66000
• LogP: 1.10
• 蒸汽压: 0.0±2.4 mmHg at 25°C
• 折射率: 1.626
• 储存条件: -20°C

布格替尼靶点实验

查看更多实验

实验名称：Cytotoxicity against mouse Ba/F3 EGFR-T790M/L858R cells assessed as inhibition of cel... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5711665

实验名称：Cytotoxicity against mouse Ba/F3 EGFR-L858R cells assessed as inhibition of cell viab... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5711664

实验名称：Cytotoxicity against mouse Ba/F3 EGFR-T790M/C797S/L858R cells assessed as inhibition ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5711667

实验名称：Thermal Shift Assay. Domain: start/stop: M1-L298 来源：ChEMBL 靶标：Cyclin-dependent kinase 2 External Id：CHEMBL5062802

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Cytotoxicity against mouse Ba/F3 EGFR-C797S/L858R cells assessed as inhibition of cel... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5711666

实验名称：Confirmatory qHTS assay for inhibitors of Glutamate pyruvate transaminase 2 (GPT2) 来源：NCGC External Id：TRND-GPT2-f1-with-DTT

实验名称：Inhibition of EGFR-C797S/T790M/del19 mutant in mouse BaF3 cells assessed as reduction... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5711675

实验名称：Inhibition of EGFR-C797S/T790M/del19 mutant in mouse BaF3 cells assessed as reduction... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5711677

实验名称：Inhibition of EGFR-C797S/T790M/del19 mutant in mouse BaF3 cells assessed as reduction... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5711676

共276条，当前第1页，共28页

1

2

3

4

5

布格替尼英文别名

• 5-Chloro-N-{4-[4-(dimethylamino)-1-piperidinyl]-2-methoxyphenyl}-N-[2-(dimethylphosphoryl)phenyl]-2,4-pyrimidinediamine
• AP26113
• Brigatinib
• ALK-IN-1