1-苄基-4-苯基-1,4-二氢吡啶-3,5-二羧酸二乙酯

• 常用名: 1-苄基-4-苯基-1,4-二氢吡啶-3,5-二羧酸二乙酯
• 英文名: Diethyl 1-benzyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate
• CAS号: 120533-76-8
• 分子量: 391.46
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₂₅NO₄
• 熔点: N/A
• 闪点: N/A

用途

BML-278 是一种 SIRT1 激活剂 (EC150: 1 μM)。BML-278 增加父本和母本原核中的 H3K9 甲基化并抑制 H3K9 乙酰化。BML-278 改善早期胚胎发育。BML-278 将原代人间充质细胞的细胞周期阻滞在 G1/S 期,并减少衰老。BML-278 减少 U937 细胞中的微管蛋白乙酰化。BML-278 还增加小鼠 C2C12 成肌细胞的线粒体密度。

名称

• 中文名: 1-苄基-4-苯基-1,4-二氢吡啶-3,5-二羧酸二乙酯
• 英文名: diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate

生物活性

• 描述: BML-278 是一种 SIRT1 激活剂 (EC150: 1 μM)。BML-278 增加父本和母本原核中的 H3K9 甲基化并抑制 H3K9 乙酰化。BML-278 改善早期胚胎发育。BML-278 将原代人间充质细胞的细胞周期阻滞在 G1/S 期,并减少衰老。BML-278 减少 U937 细胞中的微管蛋白乙酰化。BML-278 还增加小鼠 C2C12 成肌细胞的线粒体密度。
• 相关类别:
  信号通路 >> 表观遗传学 >> 抗衰老酶
  研究领域 >> 癌症
  信号通路 >> 表观遗传学 >> 组蛋白甲基转移酶
  信号通路 >> 细胞周期/DNA损伤 >> 抗衰老酶
• 靶点实验:

  SIRT1[1].

• 参考文献:

  [1]. Adamkova K, et al. SIRT1-dependent modulation of methylation and acetylation of histone H3 on lysine 9 (H3K9) in the zygotic pronuclei improves porcine embryo development. J Anim Sci Biotechnol. 2017 Nov 1;8:83.

  [2]. Mai A, et al. Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors. J Med Chem. 2009 Sep 10;52(17):5496-504.

物理化学性质

• 分子式: C₂₄H₂₅NO₄
• 分子量: 391.46
• 精确质量: 391.17800
• PSA: 55.84000
• LogP: 4.11790
• InChIKey: JOHFECBOWRGWJZ-UHFFFAOYSA-N
• SMILES: CCOC(=O)C1=CN(Cc2ccccc2)C=C(C(=O)OCC)C1c1ccccc1
• 储存条件: 室温，干燥密封

靶点实验

查看更多实验

实验名称：Activation of SIRT1 in human HaCaT cells assessed as H4K16 deacetylation at 1 uM afte... 来源：ChEMBL 靶标：NAD-dependent protein deacetylase sirtuin-1 External Id：CHEMBL4428148

实验名称：Activation of full-length GST-tagged recombinant human SIRT1 assessed as enzyme activ... 来源：ChEMBL 靶标：NAD-dependent protein deacetylase sirtuin-1 External Id：CHEMBL4428139

实验名称：Activation of full-length GST-tagged recombinant human SIRT1 assessed as enzyme activ... 来源：ChEMBL 靶标：NAD-dependent protein deacetylase sirtuin-1 External Id：CHEMBL4428140

实验名称：Activation of human SIRT1 expressed in Escherichia coli after 1 hr by fluorescent bio... 来源：ChEMBL 靶标：NAD-dependent protein deacetylase sirtuin-1 External Id：CHEMBL1049399

实验名称：Inhibition of recombinant human PDE4D assessed as phosphate release using cAMP as sub... 来源：ChEMBL 靶标：cAMP-specific 3',5'-cyclic phosphodiesterase 4D External Id：CHEMBL4428141

实验名称：Activation of AMPK/SIRT1 in human HaCaT cells assessed as nitric oxide production at ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4428142

实验名称：Inhibition of human SIRT2 expressed in Escherichia coli at 50 uM after 1 hr by fluore... 来源：ChEMBL 靶标：NAD-dependent protein deacetylase sirtuin-2 External Id：CHEMBL1049397

实验名称：Inhibition of human SIRT3 expressed in Escherichia coli at 50 uM after 1 hr by fluore... 来源：ChEMBL 靶标：NAD-dependent protein deacetylase sirtuin-3, mitochondrial External Id：CHEMBL1049398

实验名称：Inhibition of human SIRT1 expressed in Escherichia coli at 50 uM after 1 hr by fluore... 来源：ChEMBL 靶标：NAD-dependent protein deacetylase sirtuin-1 External Id：CHEMBL1049396

实验名称：Induction of apoptosis in human MCF7 cells assessed as caspase 3/7 activity at 50 uM ... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL1049409

共23条，当前第1页，共3页

1

2

3

英文别名

• .diethyl 1-benzyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate