奈拉滨

• 常用名: 奈拉滨
• 英文名: Nelarabine
• CAS号: 121032-29-9
• 分子量: 297.267
• 密度: 2.0±0.1 g/cm3
• 沸点: 721.0±70.0 °C at 760 mmHg
• 分子式: C₁₁H₁₅N₅O₅
• 熔点: 209-217ºC
• 闪点: 389.9±35.7 °C

奈拉滨用途

Nelarabine (Arranon, 506U78)是嘌呤核苷酸类似物,为DNA合成抑制剂,对肿瘤细胞的IC50为0.067-2.15 μM,可作用于T细胞急性淋巴细胞白血病。

奈拉滨名称

• 中文名: 奈拉滨
• 英文名: nelarabine
• 中文别名: 盐酸苯达莫司汀 | 萘拉滨

奈拉滨生物活性

• 描述: Nelarabine (Arranon, 506U78)是嘌呤核苷酸类似物,为DNA合成抑制剂,对肿瘤细胞的IC50为0.067-2.15 μM,可作用于T细胞急性淋巴细胞白血病。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
  研究领域 >> 癌症
• 参考文献:

  [1]. Beesley AH, et al. In vitro cytotoxicity of nelarabine, clofarabine and flavopiridol in paediatric acute lymphoblastic leukaemia. Br J Haematol. 2007 Apr;137(2):109-16.

  [2]. DeAngelo DJ, et al. Nelarabine induces complete remissions in adults with relapsed or refractory T-lineage acute lymphoblastic leukemia or lymphoblastic lymphoma: Cancer and Leukemia Group B study 19801. Blood. 2007 Jun 15;109(12):5136-42.

奈拉滨物理化学性质

• 密度: 2.0±0.1 g/cm3
• 沸点: 721.0±70.0 °C at 760 mmHg
• 熔点: 209-217ºC
• 分子式: C₁₁H₁₅N₅O₅
• 分子量: 297.267
• 闪点: 389.9±35.7 °C
• 精确质量: 297.107330
• PSA: 148.77000
• LogP: -0.58
• InChIKey: IXOXBSCIXZEQEQ-UHTZMRCNSA-N
• SMILES: COc1nc(N)nc2c1ncn2C1OC(CO)C(O)C1O
• 外观性状: 白色固体
• 蒸汽压: 0.0±2.4 mmHg at 25°C
• 折射率: 1.829
• 储存条件: 0-10°C;避免加热

奈拉滨MSDS

奈拉滨MSDS英文版

奈拉滨安全信息

• 危害码 (欧洲): Xi

奈拉滨靶点实验

查看更多实验

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu... 来源：824 External Id：CYP273

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_OPM1-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-OC1MY5-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-KMS_34-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_L363-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_OCIMY7-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-MM1R-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-mm1s-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-KMS-28PE-m4-1

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奈拉滨英文别名

• 2-Amino-9-b-D-arabinofuranosyl-6-methoxy-9H-purine
• 2-Amino-6-methoxypurinribonucleosid
• 506u
• MAY
• 9-(β-D-Arabinofuranosyl)-6-methoxy-9H-purin-2-amine
• 9-b-D-Arabinofuranosyl-6-methoxy-9H-purin-2-amine
• (2R,3S,4S,5R)-2-(2-Amino-6-methoxy-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
• 9-β-D-Arabinofuranosyl-6-methoxy-9H-purin-2-amine
• (2R,3S,4S,5R)-2-(2-amino-6-méthoxy-9H-purin-9-yl)-5-(hydroxyméthyl)tétrahydrofurane-3,4-diol
• Nelzarabine
• 9beta-D-Arabinofuranosyl-6-methoxy-9H-purin-2-amine
• Nelarabine
• O6-methyl-guanosine
• Arranon
• GW 506U78