p-chloro-alpha-[2-(dimethylamino)-1-methylethyl]-alpha-methylphenethyl alcohol hydrochloride

• 常用名: p-chloro-alpha-[2-(dimethylamino)-1-methylethyl]-alpha-methylphenethyl alcohol hydrochloride
• 英文名: p-chloro-alpha-[2-(dimethylamino)-1-methylethyl]-alpha-methylphenethyl alcohol hydrochloride
• CAS号: 1215-83-4
• 分子量: 292.24
• 密度: 1.072g/cm3
• 沸点: 356.8ºC at 760 mmHg
• 分子式: C₁₄H₂₃Cl₂NO
• 熔点: N/A
• 闪点: 169.6ºC

用途

盐酸Clobutinol是一种具有抗扭打作用的化合物。盐酸Clobutinol影响心率和血压,可用于咳嗽相关研究[1][2][3]。

名称

• 英文名: 1-(4-chlorophenyl)-4-(dimethylamino)-2,3-dimethylbutan-2-ol,hydrochloride

生物活性

• 描述: 盐酸Clobutinol是一种具有抗扭打作用的化合物。盐酸Clobutinol影响心率和血压,可用于咳嗽相关研究[1][2][3]。
• 相关类别:
  研究领域 >> 心血管疾病
  研究领域 >> 炎症/免疫
  信号通路 >> 跨膜转运 >> 钾通道
• 参考文献:

  [1]. Deisemann H, et al. Effects of common antitussive drugs on the hERG potassium channel current. J Cardiovasc Pharmacol. 2008 Dec;52(6):494-9.

  [2]. Salonen RO. Comparison of the effects of two opioid antitussives, vadocaine hydrochloride, clobutinol and lidocaine on lung mechanics in guinea-pigs. Arzneimittelforschung. 1988 Apr;38(4A):609-12.

  [3]. Takahara A, et al. Clobutinol delays ventricular repolarization in the guinea pig heart: comparison with cardiac effects of HERG K+ channel inhibitor E-4031. J Cardiovasc Pharmacol. 2009 Dec;54(6):552-9.

物理化学性质

• 密度: 1.072g/cm3
• 沸点: 356.8ºC at 760 mmHg
• 分子式: C₁₄H₂₃Cl₂NO
• 分子量: 292.24
• 闪点: 169.6ºC
• 精确质量: 291.11600
• PSA: 23.47000
• LogP: 3.63320
• InChIKey: ZMROYCGIWPNZNJ-UHFFFAOYSA-N
• SMILES: CC(CN(C)C)C(C)(O)Cc1ccc(Cl)cc1.Cl
• 蒸汽压: 1.04E-05mmHg at 25°C

毒性和生态

安全信息

• 海关编码: 2922199090

海关

• 海关编码: 2922199090
• 中文概述: 2922199090. 其他氨基醇及其醚，酯和它们的盐（但含一种以上含氧基的除外）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
• 申报要素: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
• Summary: 2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

靶点实验

查看更多实验

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu... 来源：824 External Id：CYP273

实验名称：Dicer-mediated maturation of pre-microRNA 来源：Center for Chemical Genomics, University of Michigan 靶标：N/A External Id：TargetID_659_CEMA

实验名称：p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree... 来源：824 靶标：N/A External Id：P53600

实验名称：p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce... 来源：824 靶标：N/A External Id：P53MS958

实验名称：p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary 来源：824 External Id：P53MS482

实验名称：p53 small molecule agonists, cell-based qHTS assay 来源：824 External Id：P53344

实验名称：p53 small molecule agonists, cell-based qHTS assay with human liver microsomes 来源：824 靶标：tumor suppressor p53 [Homo sapiens] External Id：P53MS233

实验名称：p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS ... 来源：824 靶标：N/A External Id：P53MS837

实验名称：p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes 来源：824 靶标：tumor suppressor p53 [Homo sapiens] External Id：P53MS898

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英文别名

• Biotertussin
• Silom
• EINECS 214-931-7
• Petoxil
• Clobutinol hydrochloride
• Pertoxil
• KAT 256
• Clobutinol HCl
• Silomat