GLPG0492

• 常用名: GLPG0492
• 英文名: GLPG0492
• CAS号: 1215085-92-9
• 分子量: 389.328
• 密度: 1.5±0.1 g/cm3
• 沸点: 544.0±60.0 °C at 760 mmHg
• 分子式: C₁₉H₁₄F₃N₃O₃
• 熔点: N/A
• 闪点: 282.8±32.9 °C

GLPG0492用途

GLPG0492是新型雄激素受体调节剂(SARM)。

GLPG0492名称

• 中文名: GLPG0492
• 英文名: GLPG0492

GLPG0492生物活性

• 描述: GLPG0492是新型雄激素受体调节剂(SARM)。
• 相关类别:
  信号通路 >> 其他 >> 雄激素受体
  研究领域 >> 其他
• 参考文献:

  [1]. Nique F, et al. Identification of a 4-(hydroxymethyl)diarylhydantoin as a selective androgen receptor modulator. J Med Chem. 2012 Oct 11;55(19):8236-47.

  [2]. Cozzoli A, et al. GLPG0492, a novel selective androgen receptor modulator, improves muscle performance in the exercised-mdx mouse model of muscular dystrophy. Pharmacol Res. 2013 Jun;72:9-24.

  [3]. Blanqué R, et al. Characterization of GLPG0492, a selective androgen receptor modulator, in a mouse model of hindlimb immobilization. BMC Musculoskelet Disord. 2014 Sep 3;15:291.

GLPG0492物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 544.0±60.0 °C at 760 mmHg
• 分子式: C₁₉H₁₄F₃N₃O₃
• 分子量: 389.328
• 闪点: 282.8±32.9 °C
• 精确质量: 389.098724
• LogP: 2.07
• InChIKey: VAJGULUVTFDTAS-GOSISDBHSA-N
• SMILES: CN1C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=O)C1(CO)c1ccccc1
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.627
• 储存条件: 2-8℃

GLPG0492靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：AUC (0 to infinity) in Sprague-Dawley rat at 10 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2188283

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：AUC (0 to infinity) in Sprague-Dawley rat at 3 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2188284

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：Oral bioavailability in Sprague-Dawley rat at 10 mg/kg 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2188282

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

实验名称：Primary qHTS for Identification of Calcium Integrin Binding Protein 1 (CIB1) Competit... 来源：NCGC External Id：CIB1-p1-p2

共39条，当前第1页，共4页

1

2

3

4

GLPG0492英文别名

• GLPG-0492
• 4-[(4S)-4-(Hydroxymethyl)-3-methyl-2,5-dioxo-4-phenyl-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile