伏马菌素 B1-13C34 溶液

• 常用名: 伏马菌素 B1-13C34 溶液
• 英文名: Fumonisin B1-13C34
• CAS号: 1217458-62-2
• 分子量: N/A
• 密度: N/A
• 沸点: N/A
• 分子式: ₁₃C₃₄H₅₉NO₁₅
• 熔点: N/A
• 闪点: 2 °C
• 符号: GHS02, GHS07
• 信号词: Danger

伏马菌素 B1-13C34 溶液用途

伏马菌素B1-13C34是13C-标记的伏马菌蛋白B1(HY-N6719)[1]。伏马菌素B1是由串珠镰刀菌产生的真菌毒素。伏马菌素B1是鞘氨醇N-酰基转移酶(神经酰胺合成酶)的有效抑制剂,并破坏鞘脂的从头生物合成。伏马菌素B1是含量最高、毒性最强的伏马菌菌素[2][3]。

伏马菌素 B1-13C34 溶液名称

• 中文名: 伏马菌素 B1-13C34 溶液
• 英文名: Fumonisin B1-13C34 solution

伏马菌素 B1-13C34 溶液生物活性

• 描述: 伏马菌素B1-13C34是13C-标记的伏马菌蛋白B1(HY-N6719)[1]。伏马菌素B1是由串珠镰刀菌产生的真菌毒素。伏马菌素B1是鞘氨醇N-酰基转移酶(神经酰胺合成酶)的有效抑制剂,并破坏鞘脂的从头生物合成。伏马菌素B1是含量最高、毒性最强的伏马菌菌素[2][3]。
• 相关类别:
  研究领域 >> 感染
• 靶点实验:

  Sphingosine N-acyltransferase[2]

• 体外研究: 氢、碳和其他元素的稳定重同位素已被纳入药物分子中,主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注,因为它可能影响药物的药代动力学和代谢谱[1] 伏马菌素B1改变猴肾细胞基因表达和信号转导通路[2] 伏马菌素B1增加鞘脂代谢的初始破坏和鞘氨醇在 LLC-PK1型肾细胞中的积累,导致大鼠星形胶质细胞凋亡型 脱氧核糖核酸损伤[2]
• 参考文献:

  [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

伏马菌素 B1-13C34 溶液物理化学性质

• 分子式: ₁₃C₃₄H₅₉NO₁₅
• 闪点: 2 °C
• InChIKey: UVBUBMSSQKOIBE-HTPIOKJKSA-N
• SMILES: CCCCC(C)C(OC(=O)CC(CC(=O)O)C(=O)O)C(CC(C)CC(O)CCCCC(O)CC(O)C(C)N)OC(=O)CC(CC(=O)O)C(=O)O
• 储存条件: −20°C

伏马菌素 B1-13C34 溶液安全信息

• 符号: GHS02, GHS07
• 信号词: Danger
• 危害声明: H225-H302 + H312 + H332-H319
• 警示性声明: P210-P280-P305 + P351 + P338
• 危害码 (欧洲): F,Xn
• 风险声明 (欧洲): 11-20/21/22-36
• 安全声明 (欧洲): 26-36/37-16
• 危险品运输编码: UN 1648 3/PG 2

伏马菌素 B1-13C34 溶液靶点实验

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实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

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伏马菌素 B1-13C34 溶液英文别名

• EINECS 808-555-8