Acamprosate D3 calcium

• 常用名: Acamprosate D3 calcium
• 英文名: Acamprosate-d3 (calcium salt)
• CAS号: 1225580-94-8
• 分子量: 223.29900
• 密度: N/A
• 沸点: N/A
• 分子式: C₅H₇CaD₃NO₄S
• 熔点: N/A
• 闪点: N/A

Acamprosate D3 calcium用途

Acamprosate D3钙是氘标记的Acamprosate钙。阿坎膦酸钙是谷氨酸能系统的GABA受体激动剂和调节剂[1][2]。

Acamprosate D3 calcium名称

• 英文名: calcium,3-[(2,2,2-trideuterioacetyl)amino]propane-1-sulfonate

Acamprosate D3 calcium生物活性

• 描述: Acamprosate D3钙是氘标记的Acamprosate钙。阿坎膦酸钙是谷氨酸能系统的GABA受体激动剂和调节剂[1][2]。
• 相关类别:
  信号通路 >> 跨膜转运 >> GABA受体
  研究领域 >> 神经疾病
  信号通路 >> 神经信号通路 >> GABA受体
• 体外研究: 氢、碳和其他元素的稳定重同位素已被纳入药物分子,主要作为药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
• 参考文献:

  [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

  [2]. Preuss UW. Commentary on the study: impact of depressive symptoms on future alcohol use in patients with co-occurring bipolar disorder and alcohol dependence: a prospective analysis in an 8-week randomized controlled trial of acamprosate (Prisciandaro et al.).Alcohol Clin Exp Res. 2012 Jun;36(6):967-9. doi: 10.1111/j.1530-0277.2012.01827.x.

  [3]. Witkiewitz K, Saville K, Hamreus K.Acamprosate for treatment of alcohol dependence: mechanisms, efficacy, and clinical utility.Ther Clin Risk Manag. 2012;8:45-53.

  [4]. Gahr M, et al. Relapse prevention in alcohol dependence: acamprosate and naltrexone as a combined pharmacological strategy.Nervenarzt. 2012 Aug 15.

  [5]. Palucha-Poniewiera A, Pilc A.Involvement of mGlu5 and NMDA receptors in the antidepressant-like effect of acamprosate in the tail suspension test.Prog Neuropsychopharmacol Biol Psychiatry. 2012 Oct 1;39(1):102-6.

  [6]. Hinton DJ, et al. Ethanol withdrawal-induced brain metabolites and the pharmacological effects of acamprosate in mice lacking ENT1.Neuropharmacology. 2012 Jun;62(8):2480-8.

Acamprosate D3 calcium物理化学性质

• 分子式: C₅H₇CaD₃NO₄S
• 分子量: 223.29900
• 精确质量: 223.01400
• PSA: 98.17000
• LogP: 1.19400
• InChIKey: WPEXQWVYZZXPJW-NIIDSAIPSA-M
• SMILES: CC(=O)NCCCS(=O)(=O)[O-].[Ca+2]
• 外观性状: 白色至灰白色固体
• 储存条件: 2-8°C

Acamprosate D3 calcium英文别名

• [2H3]-Acamprosate calcium salt
• 1-Propanesulfonic acid,3-(acetyl-2,2,2-d3-amino)-,calcium salt (2:1)