LSD1-IN-12

• 常用名: LSD1-IN-12
• 英文名: LSD1-IN-12
• CAS号: 1228143-76-7
• 分子量: 252.31
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆H₁₆N₂O
• 熔点: N/A
• 闪点: N/A

LSD1-IN-12用途

LSD1-IN-12(化合物2)是一种有效的LSD1抑制剂,Ki值分别为1.1μM(LSD1)、61μM(LSD2)、2.3μM(MAO-a)和3.5μM(MAO-B)[1]。

LSD1-IN-12名称

• 英文名: LSD1-IN-12

LSD1-IN-12生物活性

• 描述: LSD1-IN-12(化合物2)是一种有效的LSD1抑制剂,Ki值分别为1.1μM(LSD1)、61μM(LSD2)、2.3μM(MAO-a)和3.5μM(MAO-B)[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 表观遗传学 >> 组蛋白去甲基化酶
  信号通路 >> 神经信号通路 >> 单胺氧化酶
• 靶点实验:

  MAO-A:2.3 μM (Ki)

  MAO-B:3.5 μM (Ki)

• 参考文献:

  [1]. Li C, et al. Structure-Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors. J Med Chem. 2022 Mar 10;65(5):4335-4349.

LSD1-IN-12物理化学性质

• 分子式: C₁₆H₁₆N₂O
• 分子量: 252.31

LSD1-IN-12靶点实验

查看更多实验

实验名称：Inhibition of KDM1A in human NB4 cells assessed as increase in GFI1B mRNA expression ... 来源：ChEMBL 靶标：Lysine-specific histone demethylase 1A External Id：CHEMBL3782870

实验名称：Anticlonogenic activity against 129sv mouse APL blast cells assessed as inhibition of... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3784831

实验名称：Inhibition of KDM1B (unknown origin) 来源：ChEMBL 靶标：Lysine-specific histone demethylase 1B External Id：CHEMBL3782875

实验名称：Inhibition of human recombinant MAOB expressed in Pichia pastoris preincubated for 15... 来源：ChEMBL 靶标：Amine oxidase [flavin-containing] B External Id：CHEMBL3782874

实验名称：Inhibition of human recombinant MAOA expressed in Pichia pastoris preincubated for 15... 来源：ChEMBL 靶标：Amine oxidase [flavin-containing] A External Id：CHEMBL3782873

实验名称：Inhibition of human recombinant KDM1A/CoREST expressed in Escherichia coli using mono... 来源：ChEMBL 靶标：REST corepressor 1 External Id：CHEMBL3782872

实验名称：Anticlonogenic activity against human THP1 cells assessed as inhibition of colony for... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3782878

实验名称：Inhibition of KDM1A in human NB4 cells assessed as increase in CD11b mRNA expression ... 来源：ChEMBL 靶标：Lysine-specific histone demethylase 1A External Id：CHEMBL3782877

实验名称：Selectivity ratio of IC50 for human recombinant MAOA expressed in Pichia pastoris to ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3782876

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