hDDAH-1-IN-1

• 常用名: hDDAH-1-IN-1
• 英文名: hDDAH-1-IN-1
• CAS号: 1229238-69-0
• 分子量: 188.27
• 密度: N/A
• 沸点: N/A
• 分子式: C₈H₂₀N₄O
• 熔点: N/A
• 闪点: N/A

hDDAH-1-IN-1用途

hDDAH-1-IN-1 (compound 8a) 是一种高效、选择性的非氨基酸 hDDAH-1 催化位点抑制剂,Ki 值为 18 μM。

hDDAH-1-IN-1名称

• 中文名: 1-(4-Aminobutyl)-3-(2-methoxyethyl)guanidine
• 英文名: hDDAH-1-IN-1

hDDAH-1-IN-1生物活性

• 描述: hDDAH-1-IN-1 (compound 8a) 是一种高效、选择性的非氨基酸 hDDAH-1 催化位点抑制剂,Ki 值为 18 μM。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 靶点实验:

  Ki: 18 µM (hDDAH-1)[1]

• 参考文献:

  [1]. Lunk I, et al. Discovery of N-(4-Aminobutyl)-N'-(2-methoxyethyl)guanidine as the First Selective, Nonamino Acid, Catalytic Site Inhibitor of Human Dimethylarginine Dimethylaminohydrolase-1 (hDDAH-1). J Med Chem. 2019 Dec 31.

hDDAH-1-IN-1物理化学性质

• 分子式: C₈H₂₀N₄O
• 分子量: 188.27
• InChIKey: SJQJFADASWPDIQ-UHFFFAOYSA-N
• SMILES: COCCNC(N)=NCCCCN
• 储存条件: 2-8°C，密封，干燥

hDDAH-1-IN-1靶点实验

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实验名称：Inhibition of 6xHis-tagged recombinant human DDAH1 expressed in Escherichia coli BL21... 来源：ChEMBL 靶标：N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 External Id：CHEMBL4380142

实验名称：Inhibition of bovine liver arginase at 1 mM using L-arginine as substrate measured af... 来源：ChEMBL 靶标：Arginase-1 External Id：CHEMBL4380143

实验名称：Inhibition of neuronal NOS (unknown origin) assessed as formation of methemoglobin fr... 来源：ChEMBL 靶标：Nitric oxide synthase, brain External Id：CHEMBL4380144

实验名称：Inhibition of endothelial NOS (unknown origin) assessed as formation of methemoglobin... 来源：ChEMBL 靶标：Nitric oxide synthase, endothelial External Id：CHEMBL4380145

实验名称：Inhibition of iNOS (unknown origin) assessed as formation of methemoglobin from oxyhe... 来源：ChEMBL 靶标：Nitric oxide synthase, inducible External Id：CHEMBL4380146

实验名称：Cytotoxicity against human HEK293T cells assessed as effect on cell number at 0.1 to ... 来源：ChEMBL 靶标：HEK-293T External Id：CHEMBL4380153

实验名称：Cytotoxicity against human HEK293T cells assessed as effect on cell viability by meas... 来源：ChEMBL 靶标：HEK-293T External Id：CHEMBL4380154

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