UCPH-102

更新时间：2025-08-27 17:51:12

UCPH-102结构式	常用名	UCPH-102	英文名	UCPH-102
	CAS号	1229591-56-3	分子量	330.380
	密度	1.3±0.1 g/cm3	沸点	610.7±55.0 °C at 760 mmHg
	分子式	C₂₁H₁₈N₂O₂	熔点	N/A
	MSDS	N/A	闪点	323.2±31.5 °C

UCPH-102用途

UCPH-102是一种高选择性EAAT1抑制剂,IC50为0.43µM。UCPH-102对T-ALL细胞具有特异性抗增殖作用。UCPH-102还显示出良好的血脑通透性,可用于肌萎缩侧索硬化症、阿尔茨海默病、慢性疼痛和强迫症的研究[1][2][3][4]。

英文名	UCPH-102
英文别名	更多

描述	UCPH-102是一种高选择性EAAT1抑制剂,IC50为0.43µM。UCPH-102对T-ALL细胞具有特异性抗增殖作用。UCPH-102还显示出良好的血脑通透性,可用于肌萎缩侧索硬化症、阿尔茨海默病、慢性疼痛和强迫症的研究[1][2][3][4]。
相关类别	研究领域 >> 癌症信号通路 >> 其他 >> 其他研究领域 >> 神经疾病
靶点实验	IC50: 0.43 µM (EAAT1)[1].
参考文献	[1]. Huynh TH, et al. Design, synthesis and pharmacological characterization of coumarin-based fluorescent analogs of excitatory amino acid transporter subtype 1 selective inhibitors, UCPH-101 and UCPH-102. Bioorg Med Chem. 2012 Dec 1;20(23):6831-9. [2]. Haym I, et al. Bioavailability Studies and in vitro Profiling of the Selective Excitatory Amino Acid Transporter Subtype 1 (EAAT1) Inhibitor UCPH-102. ChemMedChem. 2016 Feb 17;11(4):403-19. [3]. Stanulović V S, et al. Proliferation and Survival of T-cell Acute Lymphoblastic Leukaemia Depends on mTOR-regulated Glutamine Uptake and EAAT1-dependent Conversion of Glutamine to Aspartate and Nucleotides. bioRxiv. 2020. [4]. Abrahamsen B, et al. Allosteric modulation of an excitatory amino acid transporter: the subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain. J Neurosci. 2013 Jan 16;33(3):1068-87.

密度	1.3±0.1 g/cm3
沸点	610.7±55.0 °C at 760 mmHg
分子式	C₂₁H₁₈N₂O₂
分子量	330.380
闪点	323.2±31.5 °C
精确质量	330.136841
LogP	2.68
InChIKey	XZQMHUGTNOOYFX-UHFFFAOYSA-N
SMILES	CC1C(C#N)=C(N)OC2=C1C(=O)CC(c1cccc3ccccc13)C2
蒸汽压	0.0±1.8 mmHg at 25°C
折射率	1.676

实验名称：Inhibition of human EAAT1 expressed in HEK293 cells by [3H]D-Asp uptake assay
来源：ChEMBL
靶标：Excitatory amino acid transporter 1
External Id：CHEMBL1261598

实验名称：Inhibition of human EAAT1 expressed in HEK293 cells assessed as inhibition of 3[H]-D-...
来源：ChEMBL
靶标：Excitatory amino acid transporter 1
External Id：CHEMBL2067159

实验名称：Inhibition of human EAAT3 expressed in HEK293 cells at 100 uM by [3H]D-Asp uptake ass...
来源：ChEMBL
靶标：Excitatory amino acid transporter 3
External Id：CHEMBL1261604

实验名称：Inhibition of human EAAT2 expressed in HEK293 cells at 100 uM by [3H]D-Asp uptake ass...
来源：ChEMBL
靶标：Excitatory amino acid transporter 2
External Id：CHEMBL1261600

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UCPH-102

2-Amino-4-methyl-7-(1-naphthyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile

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