Tenapanor hydrochloride

• 常用名: Tenapanor hydrochloride
• 英文名: Tenapanor hydrochloride
• CAS号: 1234365-97-9
• 分子量: 1217.970
• 密度: N/A
• 沸点: N/A
• 分子式: C₅₀H₆₈Cl₆N₈O₁₀S₂
• 熔点: N/A
• 闪点: N/A

Tenapanor hydrochloride用途

盐酸替那泊(AZD1722)是一种有效的口服活性钠/氢交换异构体3(NHE3)抑制剂。盐酸替纳帕诺主要通过减少被动细胞旁磷酸盐通量来减少肠道磷酸盐吸收。盐酸替那泊具有研究高磷血症的潜力[1][2]。

Tenapanor hydrochloride名称

• 英文名: tenapanor hydrochloride

Tenapanor hydrochloride生物活性

• 描述: 盐酸替那泊(AZD1722)是一种有效的口服活性钠/氢交换异构体3(NHE3)抑制剂。盐酸替纳帕诺主要通过减少被动细胞旁磷酸盐通量来减少肠道磷酸盐吸收。盐酸替那泊具有研究高磷血症的潜力[1][2]。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钠通道
  研究领域 >> 代谢疾病
• 体内研究: 盐酸替纳帕诺(0.15,0.5 mg/kg；p.o.)减少大鼠被动细胞旁磷酸盐吸收[1]。盐酸替那泊钠(0.15 mg/kg；p.o.；连续11天每天两次)可增加大鼠尿磷排泄的减少[2]。动物模型：大鼠(肠环模型)[1]剂量：0.15,0.5 mg/kg给药：P.o.结果：通过减少高磷酸盐餐后的尿磷酸盐和钠排泄以及增加到盲肠的钠和磷酸盐输送,减少被动细胞旁磷酸盐吸收。动物模型：8周,250g雄性Sprague–Dawley大鼠[2]剂量：0.15mg/kg与司维拉姆(0%、0.75%、1.5%和3%(wt/wt))联合给药：口服灌胃；连续11天每天两次结果：显著增加尿磷排泄的减少。
• 参考文献:

  [1]. King AJ, et al. Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability. Sci Transl Med. 2018 Aug 29;10(456):eaam6474.

  [2]. King AJ, et al. Combination treatment with tenapanor and sevelamer synergistically reduces urinary phosphorus excretion in rats. Am J Physiol Renal Physiol. 2021 Jan 1;320(1):F133-F144.

Tenapanor hydrochloride物理化学性质

• 分子式: C₅₀H₆₈Cl₆N₈O₁₀S₂
• 分子量: 1217.970
• 精确质量: 1214.263062
• InChIKey: VFRAXTZDILCRKY-OWRGXFNZSA-N
• SMILES: CN1Cc2c(Cl)cc(Cl)cc2C(c2cccc(S(=O)(=O)NCCOCCOCCNC(=O)NCCCCNC(=O)NCCOCCOCCNS(=O)(=O)c3cccc(C4CN(C)Cc5c(Cl)cc(Cl)cc54)c3)c2)C1.Cl.Cl

Tenapanor hydrochloride靶点实验

查看更多实验

实验名称：Reduction in serum phosphorus level in Sprague-Dawley rat model of uremia-associated ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3881411

实验名称：Inhibition of human NHE3-mediated sodium-dependant hydrogen ion antiport in Opossum k... 来源：ChEMBL 靶标：Sodium/hydrogen exchanger 3 External Id：CHEMBL3881404

实验名称：Inhibition of human Nap2B expressed in HEK293 cells assessed as inhibition of Pi upta... 来源：ChEMBL 靶标：Nucleosome assembly protein 1-like 4 External Id：CHEMBL3881405

实验名称：Reduction in plasma creatinine level in Sprague-Dawley rat model of uremia-associated... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3881416

实验名称：Reduction in plasma phosphorus level in Sprague-Dawley rat model of uremia-associated... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3881417

实验名称：Reduction in plasma FGF23 level in Sprague-Dawley rat model of uremia-associated vasc... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3881418

实验名称：Reduction in creatinine clearance in Sprague-Dawley rat model of uremia-associated va... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3881419

实验名称：Reduction in serum calcium level in Sprague-Dawley rat model of uremia-associated vas... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3881412

实验名称：Reduction in serum creatinine level in Sprague-Dawley rat model of uremia-associated ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3881413

实验名称：Reduction in blood urea nitrogen level in Sprague-Dawley rat model of uremia-associat... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3881414

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Tenapanor hydrochloride英文别名

• tenapanor HCl
• N,N'-(10,17-Dioxo-3,6,21,24-tetraoxa-9,11,16,18-tetraazahexacosane-1,26-diyl)bis{3-[(4S)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydro-4-isoquinolinyl]benzenesulfonamide} dihydrochloride
• tenapanor hydrochloride
• 50605O2ZNS
• RDX5791
• AZD1722 hydrochloride
• 1,1'-(butane-1,4-diyl)bis{3-[2-(2-{2-[({3-[(4S)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl]phenyl}sulfonyl)amino]ethoxy}ethoxy)ethyl]urea} dihydrochloride
• Benzenesulfonamide, N,N'-(10,17-dioxo-3,6,21,24-tetraoxa-9,11,16,18-tetraazahexacosane-1,26-diyl)bis[3-[(4S)-6,8-dichloro-1,2,3,4-tetrahydro-2-methyl-4-isoquinolinyl]-, hydrochloride (1:2)