帕那普隆

• 常用名: 帕那普隆
• 英文名: panadiplon
• CAS号: 124423-84-3
• 分子量: 335.36
• 密度: 1.5±0.1 g/cm3
• 沸点: 605.4±65.0 °C at 760 mmHg
• 分子式: C₁₈H₁₇N₅O₂
• 熔点: N/A
• 闪点: 319.9±34.3 °C

帕那普隆用途

Panadiplon(FG 10571；PNU 78875)是一种苯二氮卓类受体,是5GABAA部分激动剂。Panadiplon对5GABAA受体相对于1GABAA受体表现出选择性[1]。

帕那普隆名称

• 中文名: 帕那普隆
• 英文名: 3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-5-propan-2-ylimidazo[1,5-a]quinoxalin-4-one
• 中文别名: Pana二plon

帕那普隆生物活性

• 描述: Panadiplon(FG 10571；PNU 78875)是一种苯二氮卓类受体,是5GABAA部分激动剂。Panadiplon对5GABAA受体相对于1GABAA受体表现出选择性[1]。
• 相关类别:
  信号通路 >> 跨膜转运 >> GABA受体
  研究领域 >> 神经疾病
  信号通路 >> 神经信号通路 >> GABA受体
• 靶点实验:

  GABA(A)[1]

• 参考文献:

  [1]. Platt DM, et al. Contribution of alpha 1GABAA and alpha 5GABAA receptor subtypes to the discriminative stimulus effects of ethanol in squirrel monkeys. J Pharmacol Exp Ther. 2005 May;313(2):658-67.

帕那普隆物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 605.4±65.0 °C at 760 mmHg
• 分子式: C₁₈H₁₇N₅O₂
• 分子量: 335.36
• 闪点: 319.9±34.3 °C
• 精确质量: 335.138214
• PSA: 78.22000
• LogP: 1.70
• InChIKey: ZGEGOFCLSWVVKG-UHFFFAOYSA-N
• SMILES: CC(C)n1c(=O)c2c(-c3noc(C4CC4)n3)ncn2c2ccccc21
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.785

帕那普隆靶点实验

查看更多实验

实验名称：In vitro efficacy calculated by chlorine current assay on alpha-1-beta-2-gamma-2 (GAB... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit beta-2 External Id：CHEMBL641402

实验名称：In vivo efficacy is evaluated by percent control of cerebellar GMP levels in (drug+st... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL731773

实验名称：Ability to antagonize the muscle relaxation effect in mice caused by a benzodiazepine... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL722166

实验名称：Displacement of [3H]-Ro-15-4513 from GABA-A receptor alpha-6-beta-2-gamma-2 subunits ... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit beta-2 External Id：CHEMBL685347

实验名称：Ability to antagonize metrazole-induced seizures (clonic and tonic) in mice after int... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL822834

实验名称：Ethanol potentiation was measured against LORR 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL717705

实验名称：Ethanol potentiation activity was measured as loss of traction response in male CF-1 ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL717704

实验名称：Antagonism of metrazole-induced clonic convulsions in rats after ip injection 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL781850

实验名称：Inhibition of [3H]flunitrazepam binding to GABA-A receptor of rat cortical membranes 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-3 External Id：CHEMBL680658

实验名称：In vitro efficacy for GABA-A alpha-1-beta-2-gamma-2 subtype expressed in A293 cells i... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit beta-2 External Id：CHEMBL677789

共31条，当前第1页，共4页

1

2

3

4

帕那普隆英文别名

• 3-(5-Cyclopropyl-1,2,4-oxadiazol-3-yl)-5-(1-methylethyl)imidazo[1,5-a]quinoxalin-4(5H)-one
• panadiplon
• 3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-5-(propan-2-yl)imidazo[1,5-a]quinoxalin-4(5H)-one
• 3-(5-Cyclopropyl-1,2,4-oxadiazol-3-yl)-5-isopropylimidazo[1,5-a]quinoxalin-4(5H)-one
• Panadiplonum
• 3-(5-Cyclopropyl-1,2,4-oxadiazol-3-yl)-5-isopropylimidazo(1,5-a)quinoxalin-4(5H)-one
• Panadiplone
• UNII-V4PW0S7ZP7