AM 6545

更新时间：2024-01-09 06:04:24

AM 6545结构式	常用名	AM 6545	英文名	AM 6545
	CAS号	1245626-05-4	分子量	556.46400
	密度	N/A	沸点	N/A
	分子式	C₂₆H₂₃Cl₂N₅O₃S	熔点	N/A
	MSDS	中文版美版	闪点	N/A
	符号	GHS07	信号词	Warning

AM 6545用途

AM6545是一种外周活性大麻素受体拮抗剂,具有有限的脑渗透性。AM6545分别以1.7 nM和523 nM的Kis与CB1和CB2受体结合。AM6545是一种中性拮抗剂。AM6545可用于肥胖及其并发症的研究[1]。

英文名	5-[4-(4-cyanobut-1-ynyl)phenyl]-1-(2,4-dichlorophenyl)-N-(1,1-dioxo-1,4-thiazinan-4-yl)-4-methylpyrazole-3-carboxamide
英文别名	更多

描述	AM6545是一种外周活性大麻素受体拮抗剂,具有有限的脑渗透性。AM6545分别以1.7 nM和523 nM的Kis与CB1和CB2受体结合。AM6545是一种中性拮抗剂。AM6545可用于肥胖及其并发症的研究[1]。
相关类别	研究领域 >> 代谢疾病信号通路 >> G 蛋白偶联受体/G 蛋白 >> 大麻素受体
参考文献	[1]. N L Cluny, et al. A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents. Br J Pharmacol. 2010 Oct;161(3):629-42.

分子式	C₂₆H₂₃Cl₂N₅O₃S
分子量	556.46400
精确质量	555.09000
PSA	119.96000
LogP	5.77848

AM 6545MSDS英文版

符号	GHS07
信号词	Warning
危害声明	H319
警示性声明	P305 + P351 + P338
危险品运输编码	NONH for all modes of transport

4-氰基-1-丁炔

19596-07-7

未登录

1245626-06-5

~44%

AM 6545

1245626-05-4

文献：UNIVERSITY OF CONNECTICUT; MAKRIYANNIS, Alexandros; VEMURI, Venkata, Kiran; THOTAPALLY, Rajesh; OLSZEWSKA, Teresa Patent: WO2010/104488 A1, 2010 ; Location in patent: Page/Page column 64 ; WO 2010/104488 A1

AM 6545上游产品 1
CAS号19596-07-7 4-氰基-1-丁炔
AM 6545下游产品 0

Fasting stimulates 2-AG biosynthesis in the small intestine: role of cholinergic pathways.

Am. J. Physiol. Regul. Integr. Comp. Physiol. 309 , R805-13, (2015)

The endocannabinoids are lipid-derived signaling molecules that control feeding and energy balance by activating CB1-type cannabinoid receptors in the brain and peripheral tissues. Previous studies ha...

RasGRP3 limits Toll-like receptor-triggered inflammatory response in macrophages by activating Rap1 small GTPase.

Nat. Commun. 5 , 4657, (2014)

Host immune cells can detect and destruct invading pathogens via pattern-recognition receptors. Small Rap GTPases act as conserved molecular switches coupling extracellular signals to various cellular...

AM-6545

5-(4-(4-cyanobut-1-ynyl)phenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1,1-dioxothiomorpholino)-1H-pyrazole-3-carboxamide