N-(苄氧基)-n-((3s,4r)-6-氰基-3-羟基-2,2-二甲基苯并二氢吡喃-4-基)乙酰胺

• 常用名: N-(苄氧基)-n-((3s,4r)-6-氰基-3-羟基-2,2-二甲基苯并二氢吡喃-4-基)乙酰胺
• 英文名: Y-27152
• CAS号: 127408-30-4
• 分子量: 366.41
• 密度: 1.28g/cm3
• 沸点: 513.4ºC at 760mmHg
• 分子式: C₂₁H₂₂N₂O₄
• 熔点: N/A
• 闪点: 264.3ºC

用途

Y-27152 是KATP (Kir6)通道开放剂Y-26763的前体药物,是长效的K+ 通道开放剂,在高血压大鼠和狗在清醒状态下发挥降压作用的同时,具有更低的心动过速作用。

名称

• 中文名: N-(苄氧基)-n-((3s,4r)-6-氰基-3-羟基-2,2-二甲基苯并二氢吡喃-4-基)乙酰胺
• 英文名: N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-(phenylmethoxy)acetamide

生物活性

• 描述: Y-27152 是KATP (Kir6)通道开放剂Y-26763的前体药物,是长效的K+ 通道开放剂,在高血压大鼠和狗在清醒状态下发挥降压作用的同时,具有更低的心动过速作用。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 跨膜转运 >> 钾通道
• 靶点实验:

  K+ channel[1].

• 参考文献:

  [1]. Nakajima T, et al. Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state. J Pharmacol Exp Ther. 1992 May;261(2):730-6.

  [2]. Fukunari A, et al. Y-26763 protects the canine heart from a stunning injury through opening of the KATP channels. Eur J Pharmacol. 1997 Apr 4;323(2-3):197-204.

物理化学性质

• 密度: 1.28g/cm3
• 沸点: 513.4ºC at 760mmHg
• 分子式: C₂₁H₂₂N₂O₄
• 分子量: 366.41
• 闪点: 264.3ºC
• 精确质量: 366.15800
• PSA: 82.79000
• LogP: 3.11158
• InChIKey: RHFUXPCCELGMFC-UXHICEINSA-N
• SMILES: CC(=O)N(OCc1ccccc1)C1c2cc(C#N)ccc2OC(C)(C)C1O
• 蒸汽压: 2.29E-11mmHg at 25°C
• 折射率: 1.617

毒性和生态

靶点实验

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英文别名

• Conantokin-R
• Y-27152