Y-27152

Modify Date: 2024-01-22 08:23:03

Y-27152 structure	Common Name	Y-27152
	CAS Number	127408-30-4	Molecular Weight	366.41
	Density	1.28g/cm3	Boiling Point	513.4ºC at 760mmHg
	Molecular Formula	C₂₁H₂₂N₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	264.3ºC

Use of Y-27152

Y-27152, a prodrug of the KATP (Kir6) channel opener Y-26763, is a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state[1][2].

Name	N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-(phenylmethoxy)acetamide
Synonym	More Synonyms

Description	Y-27152, a prodrug of the KATP (Kir6) channel opener Y-26763, is a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	K+ channel[1].
References	[1]. Nakajima T, et al. Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state. J Pharmacol Exp Ther. 1992 May;261(2):730-6. [2]. Fukunari A, et al. Y-26763 protects the canine heart from a stunning injury through opening of the KATP channels. Eur J Pharmacol. 1997 Apr 4;323(2-3):197-204.

Density	1.28g/cm3
Boiling Point	513.4ºC at 760mmHg
Molecular Formula	C₂₁H₂₂N₂O₄
Molecular Weight	366.41
Flash Point	264.3ºC
Exact Mass	366.15800
PSA	82.79000
LogP	3.11158
Vapour Pressure	2.29E-11mmHg at 25°C
Index of Refraction	1.617

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AB5956333

CHEMICAL NAME :: Acetamide, N-(6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-be nzopyran-4-yl)- N-(phenylmethoxy)-, (3S-trans)-

CAS REGISTRY NUMBER :: 127408-30-4

LAST UPDATED :: 199603

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C21-H22-N2-O4

MOLECULAR WEIGHT :: 366.45

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Cardiac - other changes Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes

REFERENCE :: CDREEA Cardiovascular Drug Reviews. (Raven Press, 1185 Avenue of the Americas, New York, NY 10036) V.6- 1988- Volume(issue)/page/year: 9,372,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Cardiac - other changes Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes

REFERENCE :: CDREEA Cardiovascular Drug Reviews. (Raven Press, 1185 Avenue of the Americas, New York, NY 10036) V.6- 1988- Volume(issue)/page/year: 9,372,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Cardiac - other changes Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes

REFERENCE :: CDREEA Cardiovascular Drug Reviews. (Raven Press, 1185 Avenue of the Americas, New York, NY 10036) V.6- 1988- Volume(issue)/page/year: 9,372,1991 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 910 mg/kg/13W-I

TOXIC EFFECTS :: Cardiac - changes in heart weight Vascular - BP lowering not characterized in autonomic section Endocrine - changes in thymus weight

REFERENCE :: CDREEA Cardiovascular Drug Reviews. (Raven Press, 1185 Avenue of the Americas, New York, NY 10036) V.6- 1988- Volume(issue)/page/year: 9,372,1991

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 27300 ug/kg/13W-I

TOXIC EFFECTS :: Cardiac - changes in heart weight Vascular - BP lowering not characterized in autonomic section

REFERENCE :: CDREEA Cardiovascular Drug Reviews. (Raven Press, 1185 Avenue of the Americas, New York, NY 10036) V.6- 1988- Volume(issue)/page/year: 9,372,1991

Conantokin-R

Y-27152