半甘草异黄酮 B

• 常用名: 半甘草异黄酮 B
• 英文名: Semilicoisoflavone B
• CAS号: 129280-33-7
• 分子量: 352.337
• 密度: 1.4±0.1 g/cm3
• 沸点: 615.5±55.0 °C at 760 mmHg
• 分子式: C₂₀H₁₆O₆
• 熔点: N/A
• 闪点: 225.5±25.0 °C

半甘草异黄酮 B用途

Semilicoisoflavone B,一种异黄酮,主要来源于 Glycyrrhiza uralensis Fisch.。Semilicoisoflavone B 通过抑制 β-分泌酶-1 (BACE1) 的表达和活性来减少淀粉样蛋白 β (amyloid β,Aβ) 的分泌。Semilicoisoflavone B 主要通过增加 PPARγ 表达和抑制 STAT3 磷酸化来降低 BACE1 的表达。

半甘草异黄酮 B名称

• 中文名: 半甘草异黄酮B
• 英文名: semilicoisoflavone B

半甘草异黄酮 B生物活性

• 描述: Semilicoisoflavone B,一种异黄酮,主要来源于 Glycyrrhiza uralensis Fisch.。Semilicoisoflavone B 通过抑制 β-分泌酶-1 (BACE1) 的表达和活性来减少淀粉样蛋白 β (amyloid β,Aβ) 的分泌。Semilicoisoflavone B 主要通过增加 PPARγ 表达和抑制 STAT3 磷酸化来降低 BACE1 的表达。
• 相关类别:
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Gu MY, et al. Glycyrrhiza uralensis and Semilicoisoflavone B Reduce Aβ Secretion by Increasing PPARγ Expression and Inhibiting STAT3 Phosphorylation to Inhibit BACE1 Expression. Mol Nutr Food Res. 2018 Mar;62(6):e1700633.

半甘草异黄酮 B物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 615.5±55.0 °C at 760 mmHg
• 分子式: C₂₀H₁₆O₆
• 分子量: 352.337
• 闪点: 225.5±25.0 °C
• 精确质量: 352.094696
• PSA: 100.13000
• LogP: 4.48
• InChIKey: LWZACZCRAUQSLH-UHFFFAOYSA-N
• SMILES: CC1(C)C=Cc2cc(-c3coc4cc(O)cc(O)c4c3=O)cc(O)c2O1
• 外观性状: 油状物体
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.683
• 储存条件: 2-8℃，干燥，密闭

半甘草异黄酮 B安全信息

• 危害码 (欧洲): Xi

半甘草异黄酮 B靶点实验

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半甘草异黄酮 B英文别名

• SemilicoisoflavoneB
• 5,7-dihydroxy-3-(8-hydroxy-2,2-dimethylchromen-6-yl)chromen-4-one
• 5,7,8'-Trihydroxy-2',2'-dimethyl-2'H,4H-3,6'-bichromen-4-one
• Semilicoisoflavone B