BET-IN-20

• 常用名: BET-IN-20
• 英文名: BET-IN-20
• CAS号: 1300735-76-5
• 分子量: 412.48
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₂₄N₄O₂
• 熔点: N/A
• 闪点: N/A

BET-IN-20用途

BET-IN-20 (compound 10) 是 BRD4 BD1 的抑制剂 (IC50=1.9 nM),具有抗癌活性。BET-IN-20 可促急性髓系白血病 (AML) 细胞凋亡,将细胞周期阻滞在 G0/G1 期。BET-IN-20 还抑制 c-Myc 和 CDK6,增强 PARP 裂解。

BET-IN-20名称

• 英文名: BET-IN-20

BET-IN-20生物活性

• 描述: BET-IN-20 (compound 10) 是 BRD4 BD1 的抑制剂 (IC50=1.9 nM),具有抗癌活性。BET-IN-20 可促急性髓系白血病 (AML) 细胞凋亡,将细胞周期阻滞在 G0/G1 期。BET-IN-20 还抑制 c-Myc 和 CDK6,增强 PARP 裂解。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  信号通路 >> 表观遗传学 >> 表观遗传读者域
• 靶点实验:

  IC50: 1.9 nM (BRD4 BD1)[1]

• 参考文献:

  [1]. Yu S et al. Discovery of (R)-4-(8-methoxy-2-methyl-1-(1-phenylethy)-1H-imidazo [4, 5-c] quinnolin-7-yl)-3, 5-dimethylisoxazole as a potent and selective BET inhibitor for treatment of acute myeloid leukemia (AML) guided by FEP calculation[J]. European Journal of Medicinal Chemistry, 2023: 115924.

BET-IN-20物理化学性质

• 分子式: C₂₅H₂₄N₄O₂
• 分子量: 412.48

BET-IN-20靶点实验

查看更多实验

实验名称：Antiproliferative activity against human MM1.S cells assessed as inhibition of cell g... 来源：ChEMBL 靶标：MM1.S External Id：CHEMBL5533940

实验名称：Antiproliferative activity against human Jurkat cells assessed as inhibition of cell ... 来源：ChEMBL 靶标：Jurkat External Id：CHEMBL5533939

实验名称：Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell... 来源：ChEMBL 靶标：MOLM-13 External Id：CHEMBL5533938

实验名称：Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell ... 来源：ChEMBL 靶标：MV4-11 External Id：CHEMBL5533937

实验名称：Induction of apoptosis in human MV4-11 cells assessed as early apoptotic cells at 0.6... 来源：ChEMBL 靶标：MV4-11 External Id：CHEMBL5533936

实验名称：Induction of apoptosis in human MV4-11 cells assessed as early apoptotic cells at 1.2... 来源：ChEMBL 靶标：MV4-11 External Id：CHEMBL5533935

实验名称：Induction of apoptosis in human MV4-11 cells assessed as late apoptotic cells at 5 uM... 来源：ChEMBL 靶标：MV4-11 External Id：CHEMBL5533972

实验名称：Induction of apoptosis in human MV4-11 cells assessed as late apoptotic cells at 2.5 ... 来源：ChEMBL 靶标：MV4-11 External Id：CHEMBL5533971

实验名称：Induction of apoptosis in human MV4-11 cells assessed as late apoptotic cells at 1.25... 来源：ChEMBL 靶标：MV4-11 External Id：CHEMBL5533970

实验名称：Induction of apoptosis in human MV4-11 cells assessed as late apoptotic cells at 0.62... 来源：ChEMBL 靶标：MV4-11 External Id：CHEMBL5533969

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