宾达利

• 常用名: 宾达利
• 英文名: Bindarit
• CAS号: 130641-38-2
• 分子量: 324.374
• 密度: 1.2±0.1 g/cm3
• 沸点: 542.9±40.0 °C at 760 mmHg
• 分子式: C₁₉H₂₀N₂O₃
• 熔点: N/A
• 闪点: 282.1±27.3 °C

宾达利用途

Bindarit(AF-2838)是CCL2,CCL7和CCL8抑制剂,有抗炎活性。

宾达利名称

• 中文名: 宾达利
• 英文名: 2-[(1-benzylindazol-3-yl)methoxy]-2-methylpropanoic acid

宾达利生物活性

• 描述: Bindarit(AF-2838)是CCL2,CCL7和CCL8抑制剂,有抗炎活性。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Zoja, C., et al., Bindarit retards renal disease and prolongs survival in murine lupus autoimmune disease. Kidney Int, 1998. 53(3): p. 726-34.

  [2]. Gazzaniga, S., et al., Targeting tumor-associated macrophages and inhibition of MCP-1 reduce angiogenesis and tumor growth in a human melanoma xenograft. J Invest Dermatol, 2007. 127(8): p. 2031-41.

  [3]. Grassia, G., et al., The anti-inflammatory agent bindarit inhibits neointima formation in both rats and hyperlipidaemic mice. Cardiovasc Res, 2009. 84(3): p. 485-93.

  [4]. Zollo, M., et al., Targeting monocyte chemotactic protein-1 synthesis with bindarit induces tumor regression in prostate and breast cancer animal models. Clin Exp Metastasis, 2012. 29(6): p. 585-601.

宾达利物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 542.9±40.0 °C at 760 mmHg
• 分子式: C₁₉H₂₀N₂O₃
• 分子量: 324.374
• 闪点: 282.1±27.3 °C
• 精确质量: 324.147400
• PSA: 64.35000
• LogP: 3.44
• InChIKey: MTHORRSSURHQPZ-UHFFFAOYSA-N
• SMILES: CC(C)(OCc1nn(Cc2ccccc2)c2ccccc12)C(=O)O
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.595
• 储存条件: 室温，干燥，密封

宾达利安全信息

• 危害码 (欧洲): Xi
• 海关编码: 2933990090

宾达利海关

• 海关编码: 2933990090
• 中文概述: 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

宾达利靶点实验

查看更多实验

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Primary qHTS for Identification of Small Molecule Activators of Huntingtin-Antisense ... 来源：NCGC External Id：huntington-HTTAS8-p1-FF-overN

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_OPM1-m4-1

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宾达利英文别名

• 2-[(1-Benzyl-1H-indazol-3-yl)methoxy]-2-methylpropanoic acid
• Bindarit (USAN/INN)
• 2-((1-benzyl-1H-indazol-3-yl)methoxy)-2-methylpropanoic acid
• bindarit