K145

• 常用名: K145
• 英文名: K145
• CAS号: 1309444-75-4
• 分子量: 348.46000
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₂₄N₂O₃S
• 熔点: N/A
• 闪点: N/A

K145用途

K145是SphK2选择性抑制剂,IC50为4.3μM,在10 μM浓度时对SphK1无抑制性。

K145名称

• 中文名: K145
• 英文名: 3-(2-aminoethyl)-5-(3-(4-butoxyphenyl)propylidene)thiazolidine-2,4-dione

K145生物活性

• 描述: K145是SphK2选择性抑制剂,IC50为4.3μM,在10 μM浓度时对SphK1无抑制性。
• 相关类别:
  信号通路 >> 免疫及炎症 >> SPHK
  研究领域 >> 癌症
• 参考文献:

  [1]. Liu K, et al. Biological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a selective sphingosine kinase-2 inhibitor and anticancer agent. PLoS One. 2013;8(2):e56471.

K145物理化学性质

• 分子式: C₁₈H₂₄N₂O₃S
• 分子量: 348.46000
• 精确质量: 348.15100
• PSA: 97.93000
• LogP: 3.97430
• InChIKey: MPZXLTZVPUSTFY-SOFYXZRVSA-N
• SMILES: CCCCOc1ccc(CCC=C2SC(=O)N(CCN)C2=O)cc1
• 储存条件: 2-8℃

K145靶点实验

查看更多实验

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Primary Screen for Target Class Profiling of Small Molecule Inhibitors of Methyltrans... 来源：NCGC External Id：MTASE-p

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：Inhibition of recombinant human SPHK2 at using sphingosine as substrate after 30 mins... 来源：ChEMBL 靶标：Sphingosine kinase 2 External Id：CHEMBL4051832

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-2C

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-9B

实验名称：Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant ... 来源：NCGC External Id：s-sky_synergy-MV-411_DR-CTG72-MIPE_NPC_NPACT_Kinase-p1

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) naive MV4-11 ce... 来源：NCGC External Id：s-sky_synergy-MV-411_N-CTG72-MIPE_NPC_NPACT_Kinase-p1

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

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K145英文别名

• K145