VU 0360172 盐酸盐

• 常用名: VU 0360172 盐酸盐
• 英文名: VU 0360172 hydrochloride
• CAS号: 1309976-62-2
• 分子量: 330.78
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₁₆ClFN₂O
• 熔点: N/A
• 闪点: N/A

VU 0360172 盐酸盐用途

VU0360172 hydrochloride 是一种有效且具有选择性的 mGlu5 受体正变构调节剂,EC50 为 16 nM,Ki 为 195 nM。VU0360172 hydrochloride 能在体内刺激多磷酸肌醇 (PI) 水解,而在 mGlu5 受体基因缺失小鼠中这种水解被破坏。

VU 0360172 盐酸盐名称

• 中文名: VU 0360172 盐酸盐
• 英文名: N-Cyclobutyl-6-[(3-fluorophenyl)ethynyl]nicotinamide hydrochlorid e (1:1)

VU 0360172 盐酸盐生物活性

• 描述: VU0360172 hydrochloride 是一种有效且具有选择性的 mGlu5 受体正变构调节剂,EC50 为 16 nM,Ki 为 195 nM。VU0360172 hydrochloride 能在体内刺激多磷酸肌醇 (PI) 水解,而在 mGlu5 受体基因缺失小鼠中这种水解被破坏。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 谷氨酸受体
  研究领域 >> 神经疾病
• 靶点实验:

  mGluR5:16 nM (EC50)

  mGluR5:195 nM (Ki)

• 参考文献:

  [1]. Alice L Rodriguez, et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol Pharmacol. 2010 Dec;78(6):1105-23.

VU 0360172 盐酸盐物理化学性质

• 分子式: C₁₈H₁₆ClFN₂O
• 分子量: 330.78
• 精确质量: 330.09400
• PSA: 45.48000
• LogP: 4.27960
• InChIKey: NBGAPTWZQXSEAA-UHFFFAOYSA-N
• SMILES: Cl.O=C(NC1CCC1)c1ccc(C#Cc2cccc(F)c2)nc1
• 储存条件: -20°C

VU 0360172 盐酸盐靶点实验

查看更多实验

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Counterscreen for inhibitors of 5-meCpG-binding domain protein 2 (MBD2): TRFRET-based... 来源：The Scripps Research Institute Molecular Screening Center 靶标：E3 ubiquitin-protein ligase UHRF1 isoform 1 [Homo sapiens] External Id：UHRF1-CPGDNA_INH_TRFRET_1536_1X%INH CSRUN for MBD2-CPGDNA INH

实验名称：Optimization of novel mGluR5 positive allosteric modulators with different mechanisms... 来源：Vanderbilt Specialized Chemistry Center 靶标：metabotropic glutamate receptor 5 [Rattus norvegicus] External Id：mGlu5_PAM_SecondaryAssay1

实验名称：Luminescence-based cell-based primary high throughput screening assay for inhibitors ... 来源：The Scripps Research Institute Molecular Screening Center 靶标：nuclear receptor subfamily 0 group B member 1 [Homo sapiens] External Id：DAX1-FULL_INH_LUMI_1536_1X%INH PRUN

实验名称：uHTS identification of small molecule modulators of Rev-erb Alpha. 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：SBCCG-A1016-RevErbaLBD-Primary-Assay

实验名称：Fluorescence-based biochemical high throughput primary assay to identify inhibitors o... 来源：The Scripps Research Institute Molecular Screening Center 靶标：Phospholipase C, beta 3 (phosphatidylinositol-specific) [Homo sapiens] External Id：PLCB3_INH_QFRET_1536_1X%INH PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：ADAM10 [Homo sapiens] External Id：ADAM10_INH_QFRET_1536_1X%INH PRUN

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：Protein DAF-12, isoform a [Caenorhabditis elegans] External Id：HGDAF12_AG_LUMI_1536_1X%ACT PRUN

实验名称：Epi Absorbance-based biochemical primary high throughput screening assay to identify ... 来源：The Scripps Research Institute Molecular Screening Center 靶标：tyrosyl-DNA phosphodiesterase 2 [Homo sapiens] External Id：TPD2_INH_EPIABS_1536_1X%INH PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：abhydrolase domain-containing protein 4 isoform 1 [Mus musculus] External Id：ABHD4_INH_FP_1536_1X%INH PRUN

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VU 0360172 盐酸盐英文别名

• 3-pyr-Cytisine