维卡格雷

• 常用名: 维卡格雷
• 英文名: Vicagrel
• CAS号: 1314081-53-2
• 分子量: 379.85800
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₁₈ClNO₄S
• 熔点: N/A
• 闪点: N/A

维卡格雷用途

Vicagrel 氯吡格雷的醋酸衍生物,是一种 P2Y12 血小板抑制剂,可用于治疗血栓形成,羧酸酯酶 2 (CES2) 的底物。Vicagrel 具有良好的安全性和优异的抗血小板活性,可作为抗血小板药物。

维卡格雷名称

• 中文名: 维卡格雷
• 英文名: (S)-methyl 2-(2-acetoxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-(2-chlorophenyl)acetate

维卡格雷生物活性

• 描述: Vicagrel 氯吡格雷的醋酸衍生物,是一种 P2Y12 血小板抑制剂,可用于治疗血栓形成,羧酸酯酶 2 (CES2) 的底物。Vicagrel 具有良好的安全性和优异的抗血小板活性,可作为抗血小板药物。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> P2Y受体
• 参考文献:

  [1]. Liu C, et al. Pharmacokinetics and pharmacokinetic/pharmacodynamic relationship of vicagrel, a novel thienopyridine P2Y12 inhibitor, compared with clopidogrel in healthy Chinese subjects following single oral dosing. Eur J Pharm Sci. 2019 Jan 15;127:151-160.

  [2]. Li X, et al. Evaluation of Tolerability, Pharmacokinetics and Pharmacodynamics of Vicagrel, a Novel P2Y12 Antagonist, in Healthy Chinese Volunteers. Front Pharmacol. 2018 Jun 20;9:643.

维卡格雷物理化学性质

• 分子式: C₁₈H₁₈ClNO₄S
• 分子量: 379.85800
• 精确质量: 379.06500
• PSA: 84.08000
• LogP: 3.53710
• InChIKey: GNHHCBSBCDGWND-KRWDZBQOSA-N
• SMILES: COC(=O)C(c1ccccc1Cl)N1CCc2sc(OC(C)=O)cc2C1
• 储存条件: 2-8°C， 密封， 干燥

维卡格雷靶点实验

查看更多实验

实验名称：Toxicity in beagle dog assessed as no-observed adverse effect level 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL2045701

实验名称：Half life in Sprague-Dawley rat assessed as clopidogrel thioacetate level at 24 umol/... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2045696

实验名称：Drug metabolism in rat liver microsomes assessed as NADPH-dependent active metabolite... 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL2045693

实验名称：Antiplatelet activity in Wistar rat assessed as inhibition of ADP-induced platelet ag... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2045694

实验名称：Toxicity in mouse assessed as liver injury at 5000 mg/kg, po measured after 14 days 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2045699

实验名称：Toxicity in mouse assessed as tissue injury at 5000 mg/kg, po measured after 14 days 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2045700

实验名称：AUC (0 to infinity) in Sprague-Dawley rat assessed as clopidogrel thioacetate level a... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2045697

实验名称：Toxicity in mouse assessed as mortality at 5000 mg/kg, po measured after 14 days 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2045698

实验名称：Tmax in Sprague-Dawley rat assessed as clopidogrel thioacetate level at 24 umol/kg, p... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2045687

实验名称：Toxicity in beagle dog assessed as maximum tolerated dose 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL2044688

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维卡格雷英文别名

• (S)-methyl 2-(2-acetoxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-(2-chlorophenyl)-acetate
• methyl 2-(2-acetoxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-(2-chlorophenyl)acetate