ETP-47037

• 常用名: ETP-47037
• 英文名: ETP-47037
• CAS号: 1316760-76-5
• 分子量: 473.55188
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₂₇N₉O₃S
• 熔点: N/A
• 闪点: N/A

ETP-47037用途

ETP-47037是一种有效的PI3Kα亚型抑制剂,IC50值为0.99 nM。ETP-47037还抑制PI3Kβ、PI3Kδ和PI3Kγ亚型,IC50值分别为49.2、7.13和49.1nm。ETP-47037有望用于端粒保护的化学调节研究[1]。

ETP-47037名称

• 英文名: 5-(2-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrazolo[1,5-a]pyrazin-6-yl)pyrimidin-2-amine

ETP-47037生物活性

• 描述: ETP-47037是一种有效的PI3Kα亚型抑制剂,IC50值为0.99 nM。ETP-47037还抑制PI3Kβ、PI3Kδ和PI3Kγ亚型,IC50值分别为49.2、7.13和49.1nm。ETP-47037有望用于端粒保护的化学调节研究[1]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> PI3K
• 参考文献:

  [1]. Méndez-Pertuz M, et al. Modulation of telomere protection by the PI3K/AKT pathway. Nat Commun. 2017;8(1):1278.

ETP-47037物理化学性质

• 分子式: C₂₀H₂₇N₉O₃S
• 分子量: 473.55188
• InChIKey: XEBRAMSBPJUGET-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)N1CCN(Cc2cc3c(N4CCOCC4)nc(-c4cnc(N)nc4)cn3n2)CC1

ETP-47037靶点实验

查看更多实验

实验名称：Clearance in BALB-C mouse at 3 mg/kg, iv by LC-MS/MS analysis 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4179678

实验名称：Volume of distribution in BALB-C mouse at 3 mg/kg, iv by LC-MS/MS analysis 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4179679

实验名称：AUC (infinity) in BALB-C mouse at 3 mg/kg, iv by LC-MS/MS analysis 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4179680

实验名称：Half-life in BALB-C mouse at 3 mg/kg, iv by LC-MS/MS analysis 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4179677

实验名称：Inhibition of human AKT2 at 1 uM by filter binding assay relative to control 来源：ChEMBL 靶标：RAC-beta serine/threonine-protein kinase External Id：CHEMBL4179662

实验名称：Stability in human liver microsomes assessed as parent compound remaining at 0.5 uM a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4179663

实验名称：Stability in mouse liver microsomes assessed as parent compound remaining at 0.5 uM a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4179664

实验名称：Inhibition of CYP1A2 (unknown origin) at 10 uM relative to control 来源：ChEMBL 靶标：Cytochrome P450 1A2 External Id：CHEMBL4179665

实验名称：Inhibition of RPS6KA1 (unknown origin) at 1 uM relative to control 来源：ChEMBL 靶标：Ribosomal protein S6 kinase alpha-1 External Id：CHEMBL4179658

实验名称：Inhibition of recombinant human N-terminal GST-tagged SGK1 (M1 to L431 residues) expr... 来源：ChEMBL 靶标：Serine/threonine-protein kinase Sgk1 External Id：CHEMBL4179659

共54条，当前第1页，共6页

1

2

3

4

5