ETP-47037

Modify Date: 2025-08-30 09:38:54

ETP-47037 Structure
ETP-47037 structure
Common Name ETP-47037
CAS Number 1316760-76-5 Molecular Weight 473.55188
Density N/A Boiling Point N/A
Molecular Formula C20H27N9O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ETP-47037


ETP-47037 is a potent and inhibitor of PI3Kα isoform with an IC50 value of 0.99 nM. ETP-47037 also inhibits the PI3Kβ, PI3Kδ, and PI3Kγ isoforms, with IC50 values of 49.2, 7.13, and 49.1 nM, respectively. ETP-47037 has the potential for the research of chemical modulation of telomere protection[1].

 Names

Name 5-(2-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrazolo[1,5-a]pyrazin-6-yl)pyrimidin-2-amine

 ETP-47037 Biological Activity

Description ETP-47037 is a potent and inhibitor of PI3Kα isoform with an IC50 value of 0.99 nM. ETP-47037 also inhibits the PI3Kβ, PI3Kδ, and PI3Kγ isoforms, with IC50 values of 49.2, 7.13, and 49.1 nM, respectively. ETP-47037 has the potential for the research of chemical modulation of telomere protection[1].
Related Catalog
References

[1]. Méndez-Pertuz M, et al. Modulation of telomere protection by the PI3K/AKT pathway. Nat Commun. 2017;8(1):1278.

 Chemical & Physical Properties

Molecular Formula C20H27N9O3S
Molecular Weight 473.55188
InChIKey XEBRAMSBPJUGET-UHFFFAOYSA-N
SMILES CS(=O)(=O)N1CCN(Cc2cc3c(N4CCOCC4)nc(-c4cnc(N)nc4)cn3n2)CC1
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