Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated)

• 常用名: Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated)
• 英文名: Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated)
• CAS号: 131791-98-5
• 分子量: 1427.48000
• 密度: N/A
• 沸点: N/A
• 分子式: C₆₄H₈₆N₁₀O₂₅S
• 熔点: N/A
• 闪点: N/A

用途

Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) 是一种 Hirugen 样肽,与 Hirugen 相比,其对凝血酶具有更高的亲和力,KD < 100 nM。Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) 是一种抗血栓剂。Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) 抑制凝血酶诱导的纤维蛋白凝块形成,IC50 值为 0.087 μM。

名称

• 英文名: Suc-Phe-Glu-Pro-Ile-Pro-Glu-Glu-Tyr(OSO3H)-Leu-D-Glu-OH

生物活性

• 描述: Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) 是一种 Hirugen 样肽,与 Hirugen 相比,其对凝血酶具有更高的亲和力,KD < 100 nM。Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) 是一种抗血栓剂。Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) 抑制凝血酶诱导的纤维蛋白凝块形成,IC50 值为 0.087 μM。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 代谢酶/蛋白酶 >> 凝血酶
• 参考文献:

  [1]. Dekker RJ, et al. The variable region-1 from tissue-type plasminogen activator confers specificity for plasminogen activator inhibitor-1 to thrombin by facilitating catalysis: release of a kinetic block by a heterologous protein surface loop. J Mol Biol. 1999 Oct 29;293(3):613-27.

  [2]. Payne MH, et al. Positional effects of sulfation in hirudin and hirudin PA related anticoagulant peptides. J Med Chem. 1991 Mar;34(3):1184-7.

物理化学性质

• 分子式: C₆₄H₈₆N₁₀O₂₅S
• 分子量: 1427.48000
• 精确质量: 1426.55000
• PSA: 540.18000
• LogP: 2.81340
• InChIKey: YGKXPBZTQOZMGW-FQSUHZHRSA-N
• SMILES: CCC(C)C(NC(=O)C1CCCN1C(=O)C(CCC(=O)O)NC(=O)C(Cc1ccccc1)N1C(=O)CCC1=O)C(=O)N1CCCC1C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)O)C(=O)O

英文别名

• Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated)