Chevalone C

• 常用名: Chevalone C
• 英文名: Chevalone C
• CAS号: 1318025-77-2
• 分子量: 456.614
• 密度: 1.2±0.1 g/cm3
• 沸点: 541.2±50.0 °C at 760 mmHg
• 分子式: C₂₈H₄₀O₅
• 熔点: N/A
• 闪点: 256.5±18.1 °C

Chevalone C用途

Chevalone C是一种半萜类真菌代谢产物,具有抗疟活性,IC50值为25.00μg/mL。Chevalone C对结肠癌HCT116、肝癌HepG2和黑色素瘤A375癌细胞系具有抗增殖活性[1][2]。

Chevalone C名称

• 英文名: Chevalone C

Chevalone C生物活性

• 描述: Chevalone C是一种半萜类真菌代谢产物,具有抗疟活性,IC50值为25.00μg/mL。Chevalone C对结肠癌HCT116、肝癌HepG2和黑色素瘤A375癌细胞系具有抗增殖活性[1][2]。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 感染
• 体外研究: Chevalone C(1,10,50,100,200μM；24小时)在HepG2、HCT116和HT29细胞系(ic50=153μM、190μM、98μM)中表现出显著的细胞活力降低[2]。
• 参考文献:

  [1]. Sasiphimol Sawadsitang, et al. Antimalarial and cytotoxic constituents of Xylaria cf. cubensis PK108. Nat Prod Res. 2015;29(21):2033-6.

  [2]. M Prata-Sena, et al. Cytotoxic activity of Secondary Metabolites from Marine-derived Fungus Neosartorya siamensis in Human Cancer Cells. Phytother Res. 2016 Nov;30(11):1862-1871.

Chevalone C物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 541.2±50.0 °C at 760 mmHg
• 分子式: C₂₈H₄₀O₅
• 分子量: 456.614
• 闪点: 256.5±18.1 °C
• 精确质量: 456.287567
• LogP: 6.52
• InChIKey: ASOIHOGDYISNRH-GPTGPEQGSA-N
• SMILES: CC(=O)OC1CCC2(C)C(CCC3(C)C4Cc5c(oc(C)cc5=O)OC4(C)CCC32)C1(C)C
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.551

Chevalone C靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Primary Screen for Target Class Profiling of Small Molecule Inhibitors of Methyltrans... 来源：NCGC External Id：MTASE-p

实验名称：Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approve... 来源：NCGC 靶标：N/A External Id：OBG420

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-2C

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-9B

实验名称：Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant ... 来源：NCGC External Id：s-sky_synergy-MV-411_DR-CTG72-MIPE_NPC_NPACT_Kinase-p1

实验名称：Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) naive MV4-11 ce... 来源：NCGC External Id：s-sky_synergy-MV-411_N-CTG72-MIPE_NPC_NPACT_Kinase-p1

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：Primary qHTS for Inhibitors of N-terminal methyltransferase 1 (NTMT1): MTaseGlo Assay 来源：NCGC External Id：NTMT1-p-MTaseGlo

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

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Chevalone C英文别名

• (2S,4aR,4bR,6aS,12aS,12bR,14aR)-1,1,4a,6a,9,12b-Hexamethyl-11-oxo-2,3,4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-tetradecahydro-1H,11H-naphtho[2,1-f]pyrano[2,3-b]chromen-2-yl acetate
• Chevalone C