UNC 0631

• 常用名: UNC 0631
• 英文名: UNC0631
• CAS号: 1320288-19-4
• 分子量: 635.926
• 密度: 1.1±0.1 g/cm3
• 沸点: 763.4±70.0 °C at 760 mmHg
• 分子式: C₃₇H₆₁N₇O₂
• 熔点: N/A
• 闪点: 415.5±35.7 °C

UNC 0631用途

UNC 0631是G9a抑制剂,IC50为4nM。

UNC 0631名称

• 中文名: N-[1-(环己基甲基)-4-哌啶基]-2-[六氢-4-异丙基-1H-1,4-二氮杂卓-1-基]-6-甲氧基-7-[3-(1-哌啶基)丙氧基]-4-喹唑啉胺
• 英文名: N-[1-(Cyclohexylmethyl)-4-piperidinyl]-2-(4-isopropyl-1,4-diazepa n-1-yl)-6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine

UNC 0631生物活性

• 描述: UNC 0631是G9a抑制剂,IC50为4nM。
• 相关类别:
  信号通路 >> 表观遗传学 >> 组蛋白甲基转移酶
  研究领域 >> 癌症
• 参考文献:

  [1]. Liu F, et al. Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. J Med Chem. 2011 Sep 8;54(17):6139-50.

UNC 0631物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 763.4±70.0 °C at 760 mmHg
• 分子式: C₃₇H₆₁N₇O₂
• 分子量: 635.926
• 闪点: 415.5±35.7 °C
• 精确质量: 635.488647
• PSA: 72.46000
• LogP: 6.29
• InChIKey: XFAXSWXKPQWHDW-UHFFFAOYSA-N
• SMILES: COc1cc2c(NC3CCN(CC4CCCCC4)CC3)nc(N3CCCN(C(C)C)CC3)nc2cc1OCCCN1CCCCC1
• 蒸汽压: 0.0±2.6 mmHg at 25°C
• 折射率: 1.579
• 储存条件: 2-8℃

UNC 0631靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cellular viability qHTS for adrenocortical cancer (ACC) cell line SW-13 来源：NCGC 靶标：N/A External Id：ACC-ATC-p1-SW13-72hr

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Cellular viability qHTS for adrenocortical cancer (ACC) cell line NCI-H295R 来源：NCGC 靶标：N/A External Id：ACC-ATC-p1-H295R-72hr

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

实验名称：NCATS Human Liver Microsomal (HLM) Stability Profiling 来源：NCGC 靶标：N/A External Id：ADME-HLM1

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UNC 0631英文别名

• N-(1-(benzo[d][1,3]dioxol-5-yl)propyl)-4-methylbenzenesulfonamide
• N-(1-(cyclohexylmethyl)piperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine
• Benzenesulfonamide,N-[1-(1,3-benzodioxol-5-yl)propyl]-4-methyl
• UNC0631
• UNC 0631