Tirofiban-d9 hydrochloride

• 常用名: Tirofiban-d9 hydrochloride
• 英文名: Tirofiban-d9 hydrochloride
• CAS号: 1331911-68-2
• 分子量: 486.11300
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₈ClD₉N₂O₅S
• 熔点: N/A
• 闪点: N/A

Tirofiban-d9 hydrochloride用途

替罗非班-d9(L700462-d9)盐酸盐是氘标记的替罗非班。替罗非班(L700462)是一种有效的非肽糖蛋白IIb/IIIa(整合素αIIb)拮抗剂[1][2]。

Tirofiban-d9 hydrochloride名称

• 中文名: 替罗非班-丁基-d9,盐酸盐
• 英文名: (2S)-2-(1,1,2,2,3,3,4,4,4-nonadeuteriobutylsulfonylamino)-3-[4-(4-piperidin-4-ylbutoxy)phenyl]propanoic acid,hydrochloride

Tirofiban-d9 hydrochloride生物活性

• 描述: 替罗非班-d9(L700462-d9)盐酸盐是氘标记的替罗非班。替罗非班(L700462)是一种有效的非肽糖蛋白IIb/IIIa(整合素αIIb)拮抗剂[1][2]。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 细胞骨架 >> Integrin
• 体外研究: 氢、碳和其他元素的稳定重同位素已被纳入药物分子,主要作为药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
• 参考文献:

  [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

  [2]. Winter JP, Juergens CP. The role of tirofiban in the management of coronary artery disease. Cardiovasc Hematol Disord Drug Targets. 2008 Jun;8(2):138-46.

  [3]. van 't Hof AW, Valgimigli M. Defining the role of platelet glycoprotein receptor inhibitors in STEMI: focus on tirofiban. Drugs. 2009;69(1):85-100.

  [4]. Valgimigli M, Biondi-Zoccai G, Tebaldi M et al. Tirofiban as adjunctive therapy for acute coronary syndromes and percutaneous coronary intervention: a meta-analysis of randomized trials. Eur Heart J. 2010 Jan;31(1):35-49.

  [5]. Valgimigli M, Tebaldi M. Safety evaluation of tirofiban. Expert Opin Drug Saf. 2010 Sep;9(5):801-19.

  [6]. Diaz JF, Cardenal R, Gomez-Manchero A, Sanchez-Gonzalez C. Safety and efficacy of tirofiban as adjunctive therapy for patients with ST-elevation myocardial infarction: a comparison versus placebo and abciximab. Cardiovasc Hematol Agents Med Chem. 2011 Jul 1;9(3):147-53.

Tirofiban-d9 hydrochloride物理化学性质

• 分子式: C₂₂H₂₈ClD₉N₂O₅S
• 分子量: 486.11300
• 精确质量: 485.26800
• PSA: 113.11000
• LogP: 5.55300
• InChIKey: KPKFFYOMPGOQRP-MDIJXIJDSA-N
• SMILES: CCCCS(=O)(=O)NC(Cc1ccc(OCCCCC2CCNCC2)cc1)C(=O)O.Cl

Tirofiban-d9 hydrochloride英文别名

• Tirofiban-butyl-d9,Hydrochloride
• Tirofiban-d9 Hydrochloride