AG 538

• 常用名: AG 538
• 英文名: AG 538
• CAS号: 133550-18-2
• 分子量: 297.262
• 密度: 1.5±0.1 g/cm3
• 沸点: 637.5±55.0 °C at 760 mmHg
• 分子式: C₁₆H₁₁NO₅
• 熔点: N/A
• 闪点: 339.3±31.5 °C

AG 538用途

AG 538 是一种有效的 IGF-1 受体激酶竞争性抑制剂,IC50 为 400 nM。

AG 538名称

• 英文名: Tyrphostin AG 538

AG 538生物活性

• 描述: AG 538 是一种有效的 IGF-1 受体激酶竞争性抑制剂,IC50 为 400 nM。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 蛋白酪氨酸激酶 >> IGF-1R
• 参考文献:

  [1]. G Blum, et al. Substrate Competitive Inhibitors of IGF-1 Receptor Kinase. Biochemistry. 2000 Dec 26;39(51):15705-12.

AG 538物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 637.5±55.0 °C at 760 mmHg
• 分子式: C₁₆H₁₁NO₅
• 分子量: 297.262
• 闪点: 339.3±31.5 °C
• 精确质量: 297.063721
• PSA: 121.78000
• LogP: 1.79
• InChIKey: CANOJKGQDCJDOX-VZUCSPMQSA-N
• SMILES: N#CC(=Cc1ccc(O)c(O)c1)C(=O)c1ccc(O)c(O)c1
• 蒸汽压: 0.0±2.0 mmHg at 25°C
• 折射率: 1.754

AG 538靶点实验

查看更多实验

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：Inhibition of HER14 serum dependent cell proliferation without EGF 来源：ChEMBL 靶标：NIH3T3 External Id：CHEMBL664972

实验名称：MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_SinglePoint... 来源：Broad Institute 靶标：N/A External Id：2084-01_Activator_SinglePoint_HTS_Activity

实验名称：Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberc... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：GDH-TPI_INH_ABS_1536_1X%INH CSRUN

实验名称：qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity 来源：NCGC External Id：HERG01

实验名称：qHTS for Inhibitors of TGF-b: Cytotox Counterscreen 来源：NCGC 靶标：N/A External Id：SMAD3201

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AG 538英文别名

• AGS 199
• (2E)-2-(3,4-Dihydroxybenzoyl)-3-(3,4-dihydroxyphenyl)acrylonitrile
• AG538
• AG 538
• 3,4-dihydroxy-α-(3,4-dihydroxybenzoyl)-cis-cinnamonitrile
• tyrphostin AG 538