AG 538

Modify Date: 2025-08-25 20:38:53

AG 538 Structure
AG 538 structure
Common Name AG 538
CAS Number 133550-18-2 Molecular Weight 297.262
Density 1.5±0.1 g/cm3 Boiling Point 637.5±55.0 °C at 760 mmHg
Molecular Formula C16H11NO5 Melting Point N/A
MSDS N/A Flash Point 339.3±31.5 °C

 Use of AG 538


AG 538 is a potent, competitive inhibitor of IGF-1 receptor kinase, with an IC50 of 400 nM[1].

 Names

Name Tyrphostin AG 538
Synonym More Synonyms

 AG 538 Biological Activity

Description AG 538 is a potent, competitive inhibitor of IGF-1 receptor kinase, with an IC50 of 400 nM[1].
Related Catalog
References

[1]. G Blum, et al. Substrate Competitive Inhibitors of IGF-1 Receptor Kinase. Biochemistry. 2000 Dec 26;39(51):15705-12.  

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 637.5±55.0 °C at 760 mmHg
Molecular Formula C16H11NO5
Molecular Weight 297.262
Flash Point 339.3±31.5 °C
Exact Mass 297.063721
PSA 121.78000
LogP 1.79
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.754

 Synonyms

AGS 199
(2E)-2-(3,4-Dihydroxybenzoyl)-3-(3,4-dihydroxyphenyl)acrylonitrile
AG538
Benzenepropanenitrile, α-[(3,4-dihydroxyphenyl)methylene]-3,4-dihydroxy-β-oxo-, (αE)-
AG 538
3,4-dihydroxy-α-(3,4-dihydroxybenzoyl)-cis-cinnamonitrile
tyrphostin AG 538
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