EGFR-IN-16

• 常用名: EGFR-IN-16
• 英文名: EGFR-IN-16
• CAS号: 133550-22-8
• 分子量: 265.26
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆H₁₁NO₃
• 熔点: N/A
• 闪点: N/A

EGFR-IN-16用途

EGFR-IN-16(化合物3)是一种有效的EGFR抑制剂,EGFR和HER-2的pIC50分别为4.85和4.74[1]。

EGFR-IN-16名称

• 中文名: (E)-2-benzoyl-3-(3,4-dihydroxyphenyl)prop-2-enenitrile
• 英文名: EGFR-IN-16

EGFR-IN-16生物活性

• 描述: EGFR-IN-16(化合物3)是一种有效的EGFR抑制剂,EGFR和HER-2的pIC50分别为4.85和4.74[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> JAK/STAT信号通路 >> EGFR
  信号通路 >> 蛋白酪氨酸激酶 >> EGFR
• 靶点实验:

  EGFR:4.85 (pIC50)

  HER2:4.74 (pIC50)

• 参考文献:

  [1]. Kamath S, et al. Receptor-guided alignment-based comparative 3D-QSAR studies of benzylidene malonitrile tyrphostins as EGFR and HER-2 kinase inhibitors. J Med Chem. 2003;46(22):4657-4668.

EGFR-IN-16物理化学性质

• 分子式: C₁₆H₁₁NO₃
• 分子量: 265.26
• InChIKey: QBKFKKGORMOFFU-MDWZMJQESA-N
• SMILES: N#CC(=Cc1ccc(O)c(O)c1)C(=O)c1ccccc1
• 储存条件: 2-8°C，密封，干燥

EGFR-IN-16靶点实验

查看更多实验

实验名称：In vitro inhibition of HER1 autophosphorylation. 来源：ChEMBL 靶标：Epidermal growth factor receptor External Id：CHEMBL676152

实验名称：Inhibition of HER14 (human EGFR overexpressing NIH3T3) cell growth in the absence of ... 来源：ChEMBL 靶标：NIH3T3 External Id：CHEMBL664973

实验名称：EGFR assay from Article 10.1021/jm00110a022: "Tyrphostins. 2. Heterocyclic and alpha-... 来源：BindingDB 靶标：N/A External Id：BindingDB_603_1

实验名称：Inhibition of polyGAT phosphorylation 来源：ChEMBL 靶标：Epidermal growth factor receptor External Id：CHEMBL763200

实验名称：Inhibition of HER14 (human EGFR overexpressing) cell proliferation. 来源：ChEMBL 靶标：Epidermal growth factor receptor External Id：CHEMBL701406

实验名称：Inhibitory activity tested against protein kinase HER-2 来源：ChEMBL 靶标：Receptor tyrosine-protein kinase erbB-2 External Id：CHEMBL769140

实验名称：Inhibitory activity against epidermal growth factor receptor (EGFR) 来源：ChEMBL 靶标：Epidermal growth factor receptor External Id：CHEMBL676067

实验名称：Inhibition of EGFR in human A431 cells 来源：ChEMBL 靶标：Epidermal growth factor receptor External Id：CHEMBL941404

实验名称：In vitro inhibition of ERBB2 receptor kinase autophosphorylation. 来源：ChEMBL 靶标：Receptor tyrosine-protein kinase erbB-2 External Id：CHEMBL673948

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