2-NAPHTHALENAMINE, 1,2,3,4-TETRAHYDRO-N-2-PROPYNYL-, HYDROCHLORIDE

• 常用名: 2-NAPHTHALENAMINE, 1,2,3,4-TETRAHYDRO-N-2-PROPYNYL-, HYDROCHLORIDE
• 英文名: 2-NAPHTHALENAMINE, 1,2,3,4-TETRAHYDRO-N-2-PROPYNYL-, HYDROCHLORIDE
• CAS号: 134467-58-6
• 分子量: 221.726
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₃H₁₆ClN
• 熔点: N/A
• 闪点: N/A

用途

2-PAT是拉沙吉林和塞来吉林的类似物,是一种可逆的MAO-a抑制剂,IC50为0.721µM。2-PAT是MAO-B的灭活剂,IC50为14.6µM。2-PAT有可能用于帕金森病和抑郁症研究【1】。

名称

• 英文名: N-(2-Propyn-1-yl)-1,2,3,4-tetrahydro-2-naphthalenamine hydrochloride (1:1)

生物活性

• 描述: 2-PAT是拉沙吉林和塞来吉林的类似物,是一种可逆的MAO-a抑制剂,IC50为0.721µM。2-PAT是MAO-B的灭活剂,IC50为14.6µM。2-PAT有可能用于帕金森病和抑郁症研究【1】。
• 相关类别:
  信号通路 >> 神经信号通路 >> 单胺氧化酶
  研究领域 >> 神经疾病
• 靶点实验:

  MAO-A:0.721 μM (IC50)

  MAO-B:14.6 μM (IC50)

• 参考文献:

  [1]. Letitia Meiring, et al. The evaluation of N-propargylamine-2-aminotetralin as an inhibitor of monoamine oxidase. Bioorg Med Chem Lett. 2022 Jul 1;67:128746.

物理化学性质

• 分子式: C₁₃H₁₆ClN
• 分子量: 221.726
• 精确质量: 221.097122

靶点实验

查看更多实验

实验名称：Inhibition of human recombinant MAOA assessed as enzyme activity recovery level at 4 ... 来源：ChEMBL 靶标：Amine oxidase [flavin-containing] A External Id：CHEMBL5147827

实验名称：Inhibition of human recombinant MAOB assessed as enzyme activity recovery level at 4 ... 来源：ChEMBL 靶标：Amine oxidase [flavin-containing] B External Id：CHEMBL5147828

实验名称：Selectivity index, ratio of IC50 for inhibition of human recombinant MAOA to IC50 for... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5147824

实验名称：Inhibition of human recombinant MAOA assessed as enzyme activity recovery level at 4 ... 来源：ChEMBL 靶标：Amine oxidase [flavin-containing] A External Id：CHEMBL5147825

实验名称：Resistance index, ratio of IC50 for toloxatone to IC50 for test compound for inhibiti... 来源：ChEMBL 靶标：Amine oxidase [flavin-containing] A External Id：CHEMBL5147818

实验名称：Inhibition of human recombinant MAOB assessed as enzyme activity recovery level at 4 ... 来源：ChEMBL 靶标：Amine oxidase [flavin-containing] B External Id：CHEMBL5147830

实验名称：Time dependent inhibition of human recombinant MAOB at 414.6 uM using kynuramine subs... 来源：ChEMBL 靶标：Amine oxidase [flavin-containing] B External Id：CHEMBL5147831

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英文别名

• N-(2-Propyn-1-yl)-1,2,3,4-tetrahydro-2-naphthalenamine hydrochloride (1:1)
• MFCD09998861
• 2-Naphthalenamine, 1,2,3,4-tetrahydro-N-2-propyn-1-yl-, hydrochloride (1:1)