(S)-Ceralasertib

• 常用名: (S)-Ceralasertib
• 英文名: (S)-Ceralasertib
• CAS号: 1352226-87-9
• 分子量: 412.51
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₂₄N₆O₂S
• 熔点: N/A
• 闪点: N/A

(S)-Ceralasertib用途

(S)-Ceralasertib 从专利 WO2011154737A1 中获取,化合物 II,IC50 为 2.578 nM。(S)-Ceralasertib 是一种有效的选择性亚砜亚胺吗啉代嘧啶 ATR 抑制剂,具有优异的临床前物化和药代动力学 (PK) 特征。(S)-Ceralasertib 水溶性改善,并且消除 CYP3A4 时间依赖性抑制。

(S)-Ceralasertib名称

• 英文名: (S)-Ceralasertib

(S)-Ceralasertib生物活性

• 描述: (S)-Ceralasertib 从专利 WO2011154737A1 中获取,化合物 II,IC50 为 2.578 nM。(S)-Ceralasertib 是一种有效的选择性亚砜亚胺吗啉代嘧啶 ATR 抑制剂,具有优异的临床前物化和药代动力学 (PK) 特征。(S)-Ceralasertib 水溶性改善,并且消除 CYP3A4 时间依赖性抑制。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> ATM/ATR
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> ATM/ATR
• 参考文献:

  [1]. By Foote, et al. Morpholinopyrimidines as ATR kinase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cancer. PCT Int. Appl. (2011), WO 2011154737 A1 20111215.

  [2]. Foote KM, et al. Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutatedand Rad3 Related (ATR) Kinase with Application as an Anticancer Agent. J Med Chem. 2018 Nov 21;61(22):9889-9907.

(S)-Ceralasertib物理化学性质

• 分子式: C₂₀H₂₄N₆O₂S
• 分子量: 412.51
• InChIKey: OHUHVTCQTUDPIJ-MUWSIPGASA-N
• SMILES: CC1COCCN1c1cc(C2(S(C)(=N)=O)CC2)nc(-c2ccnc3[nH]ccc23)n1
• 储存条件: -20°C，密闭，干燥

(S)-Ceralasertib靶点实验

查看更多实验

实验名称：Octanol-phosphate buffer partition co-efficient, log D of the compound at 10 uM at pH... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4269679

实验名称：Inhibition of ATR in human HT29 cells after 60 mins by Hoechst 33258 staining-based a... 来源：ChEMBL 靶标：Serine/threonine-protein kinase ATR External Id：CHEMBL4269678

实验名称：Aqueous solubility in pH 7.4 phosphate buffer after 24 hrs by LC-UV-MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4269681

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Time dependent inhibition of CYP3A4 in human liver microsomes at 10 uM using midazola... 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL4269680

实验名称：Inhibition of ATR in human HeLa cell nuclear extract using GST-fused p53N66 as substr... 来源：ChEMBL 靶标：Serine/threonine-protein kinase ATR External Id：CHEMBL4269677

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

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