clathrodin

• 常用名: clathrodin
• 英文名: clathrodin
• CAS号: 135383-64-1
• 分子量: 231.25400
• 密度: 1.382g/cm3
• 沸点: N/A
• 分子式: C₁₁H₁₃N₅O
• 熔点: N/A
• 闪点: N/A

clathrodin用途

克拉丝汀是一种海洋生物碱,可从Agelas属海绵中分离出来。Clathrodin是电压门控钠(NaV)通道的调节剂。克拉斯罗定是一种影响钠通道离子传导的钠通道神经毒素[1][2]。

clathrodin名称

• 英文名: N-[(E)-3-(2-amino-1H-imidazol-5-yl)prop-2-enyl]-1H-pyrrole-2-carboxamide

clathrodin生物活性

• 描述: 克拉丝汀是一种海洋生物碱,可从Agelas属海绵中分离出来。Clathrodin是电压门控钠(NaV)通道的调节剂。克拉斯罗定是一种影响钠通道离子传导的钠通道神经毒素[1][2]。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钠通道
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Rentas AL, et al. Effect of alkaloid toxins from tropical marine sponges on membrane sodium currents. Toxicon. 1995 Apr;33(4):491-7.

clathrodin物理化学性质

• 密度: 1.382g/cm3
• 分子式: C₁₁H₁₃N₅O
• 分子量: 231.25400
• 精确质量: 231.11200
• PSA: 100.32000
• LogP: 1.08420
• InChIKey: PJKFCZYTTBYEHL-HNQUOIGGSA-N
• SMILES: Nc1ncc(C=CCNC(=O)c2ccc[nH]2)[nH]1
• 折射率: 1.726

clathrodin靶点实验

查看更多实验

实验名称：Inhibition of human Kv1.1 expressed in CHO cells at -80 mV holding potential by whole... 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily A member 1 External Id：CHEMBL4193567

实验名称：HIV Cellular Data 来源：NIAID 靶标：N/A External Id：HIV Cellular Data

实验名称：Inhibition of human Kv1.6 expressed in CHO cells at -80 mV holding potential by whole... 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily A member 6 External Id：CHEMBL4193572

实验名称：Induction of apoptosis in human HepG2 cells at 50 uM incubated for 24 hrs by Annexin ... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL3624045

实验名称：Cytotoxicity against CHOK1 cells 来源：ChEMBL 靶标：CHO-K1 External Id：CHEMBL1019288

实验名称：Inhibition of human Kv1.3 expressed in CHO cells at -80 mV holding potential by whole... 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily A member 3 External Id：CHEMBL4193569

实验名称：Inhibition of human Kv1.2 expressed in CHO cells at -80 mV holding potential by whole... 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily A member 2 External Id：CHEMBL4193568

实验名称：Inhibition of human Kv1.5 expressed in CHO cells at -80 mV holding potential by whole... 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily A member 5 External Id：CHEMBL4193571

实验名称：Inhibition of cholinergic receptor in frog skeletal muscle at 0.1 uM to 1000 uM 来源：ChEMBL 靶标：N/A External Id：CHEMBL1019289

实验名称：Inhibition of human Kv1.4 expressed in CHO cells at -80 mV holding potential by whole... 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily A member 4 External Id：CHEMBL4193570

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clathrodin英文别名

• Clathrodine
• Clathrodin
• N-(3-(2-Imino-2,3-dihydro-1H-imidazol-4-yl)-2-propenyl)-1H-pyrrole-2-carboxamide
• 1H-Pyrrole-2-carboxamide,N-(3-(2-amino-1H-imidazol-4-yl)-2-propenyl)-,(E)