聚乙二醇纳诺醇

• 常用名: 聚乙二醇纳诺醇
• 英文名: Naloxegol oxalate
• CAS号: 1354744-91-4
• 分子量: 741.820
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₆H₅₅NO₁₅
• 熔点: N/A
• 闪点: N/A

聚乙二醇纳诺醇用途

Naloxegol oxalate (NKTR-118 oxalate; AZ-13337019 oxalate) 是阿片受体拮抗剂。

聚乙二醇纳诺醇名称

• 中文名: 聚乙二醇纳诺醇
• 英文名: (4R,4aS,7S,7aR,12bS)-7-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol,oxalic acid

聚乙二醇纳诺醇生物活性

• 描述: Naloxegol oxalate (NKTR-118 oxalate; AZ-13337019 oxalate) 是阿片受体拮抗剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 阿片受体
  信号通路 >> 神经信号通路 >> 阿片受体
  研究领域 >> 神经疾病
• 靶点实验:

  Opioid receptor[1]

• 参考文献:

  [1]. Garnock-Jones KP, et al. Naloxegol: a review of its use in patients with opioid-induced constipation. Drugs. 2015 Mar;75(4):419-25.

  [2]. Yoon SC, et al. Naloxegol in opioid-induced constipation: a new paradigm in the treatment of a common problem. Patient Prefer Adherence. 2017 Jul 24;11:1265-1271.

聚乙二醇纳诺醇物理化学性质

• 分子式: C₃₆H₅₅NO₁₅
• 分子量: 741.820
• 精确质量: 741.357178
• PSA: 201.37000
• LogP: 0.95700
• InChIKey: MNYIRXLCPODKLG-VUTNLTPYSA-N
• SMILES: C=CCN1CCC23c4c5ccc(O)c4OC2C(OCCOCCOCCOCCOCCOCCOCCOC)CCC3(O)C1C5.O=C(O)C(=O)O
• 储存条件: 2-8℃

聚乙二醇纳诺醇靶点实验

查看更多实验

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

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聚乙二醇纳诺醇英文别名

• NKTR-118 oxalate
• Naloxegol oxalate (USAN)
• Morphinan-3,14-diol, 4,5-epoxy-6-(3,6,9,12,15,18,21-heptaoxadocos-1-yloxy)-17-(2-propen-1-yl)-, (5α,6α)-, ethanedioate (1:1) (salt)
• Naloxegol oxalate
• (5α,6α)-17-Allyl-6-(2,5,8,11,14,17,20-heptaoxadocosan-22-yloxy)-4,5-epoxymorphinan-3,14-diol ethanedioate (1:1)
• UNII-65I14TNM33
• 4,5α-epoxy-6α-[(3,6,7,12,15,18,21-heptaoxadocosyl)oxy]-17-(prop-2-enyl)morphinan-3,14-diol hydrogen ethanedioate