MOMIPP

• 常用名: MOMIPP
• 英文名: MOMIPP
• CAS号: 1363421-46-8
• 分子量: 292.33
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₁₆N₂O₂
• 熔点: N/A
• 闪点: N/A

MOMIPP用途

MOMIPP是一种大细胞增殖诱导剂,是一种PIKfyve抑制剂。MOMIPP穿透血脑屏障(BBB)[1][2]。

MOMIPP名称

• 英文名: trans-3-(5-methoxy-2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-2-propen-1-one

MOMIPP生物活性

• 描述: MOMIPP是一种大细胞增殖诱导剂,是一种PIKfyve抑制剂。MOMIPP穿透血脑屏障(BBB)[1][2]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> PIKfyve
• 体外研究: MOMIPP可诱导强烈的巨嗜酸细胞增生,导致培养的胶质母细胞瘤细胞在低微摩尔浓度下发生甲硫氨酸中毒[1]。在U373和Hs683细胞系中,3µM的MOMIPP诱导细胞空泡化[1]。MOMIPP(10 μM)引起葡萄糖摄取和糖酵解代谢的早期中断。MOMIPP选择性激活JNK1/2应激激酶途径,导致c-Jun、Bcl-2和Bcl-xL的磷酸化[2]。Western Blot分析[2]细胞系：U251细胞浓度：10 μM培养时间：4 小时或24小时 结果：激活JNK应激激酶通路。
• 体内研究: 莫米普(80岁) mg/kg；i、 p。；每日一次；连续15天)在抑制脑内胶质母细胞瘤异种移植进展方面显示出中度有效[2]。动物模型：无胸腺CrTac:NCR-Foxn1小鼠(雌性,7-8 周)[2]剂量：80 mg/kg给药：腹腔注射。；每日一次；连续15天结果：抑制异种脑内胶质母细胞瘤的进展。
• 参考文献:

  [1]. Margaux Colin, et al. Dysregulation of Macropinocytosis Processes in Glioblastomas May Be Exploited to Increase Intracellular Anti-Cancer Drug Levels: The Example of Temozolomide. Cancers (Basel). 2019 Mar 22;11(3):411.

  [2]. Zehui Li, et al. The JNK signaling pathway plays a key role in methuosis (non-apoptotic cell death) induced by MOMIPP in glioblastoma. BMC Cancer. 2019 Jan 16;19(1):77.

MOMIPP物理化学性质

• 分子式: C₁₈H₁₆N₂O₂
• 分子量: 292.33
• 精确质量: 292.12100
• PSA: 54.98000
• LogP: 3.77600

MOMIPP靶点实验

查看更多实验

实验名称：Cell cycle arrest in human U251 cells assessed as accumulation at S phase at 3 uM aft... 来源：ChEMBL 靶标：U-251 External Id：CHEMBL3424728

实验名称：Induction of methuosis in human MDA-MB-231 cells assessed as increase in vacuole form... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL4124741

实验名称：Disruption of microtubule organization in human U251 cells at 3 uM after 24 hrs by DA... 来源：ChEMBL 靶标：U-251 External Id：CHEMBL3424729

实验名称：Induction of methuosis in human MDA-MB-231 cells assessed as increase in vacuole form... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL4124742

实验名称：Cell cycle arrest in human U251 cells assessed as accumulation at G2/M phase at 0.1 u... 来源：ChEMBL 靶标：U-251 External Id：CHEMBL3424726

实验名称：Cell cycle arrest in human U251 cells assessed as accumulation at S phase at 0.1 uM a... 来源：ChEMBL 靶标：U-251 External Id：CHEMBL3424727

实验名称：Inhibition of tubulin polymerization in in human U251 cells at 0.1 uM after 4 hrs by ... 来源：ChEMBL 靶标：Tubulin alpha-3C chain External Id：CHEMBL3424732

实验名称：Induction of methuosis in human HeLa cells at 1 uM preincubated for 3 hrs followed by... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL5534382

实验名称：Induction of methuosis in human HeLa cells at 1 uM incubated for 3 hrs by microscopic... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL5534381

实验名称：Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B colorimetric a... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3866042

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MOMIPP英文别名

• trans-3-(5-methoxy-2-methylindol-3-yl)-1-(4-pyridinyl)-2-propen-1-one