SKLB4771

• 常用名: SKLB4771
• 英文名: FLT3-IN-1
• CAS号: 1370256-78-2
• 分子量: 537.65700
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₂₇N₇O₃S₂
• 熔点: N/A
• 闪点: N/A

SKLB4771用途

SKLB4771是Flt3新型高效抑制剂,IC50值10nM。

SKLB4771名称

• 中文名: SKLB4771
• 英文名: 1-{5-[7-(3-morpholinopropoxy)quinazolin-4-ylthio][1,3,4]thiadiazol-2-yl}-3-p-tolylurea

SKLB4771生物活性

• 描述: SKLB4771是Flt3新型高效抑制剂,IC50值10nM。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> FLT3
  研究领域 >> 癌症
• 参考文献:

  [1]. Li WW, et al. Discovery of the novel potent and selective FLT3 inhibitor 1-{5-[7-(3- morpholinopropoxy)quinazolin-4-ylthio]-[1,3,4]thiadiazol-2-yl}-3-p-tolylurea and its anti-acute myeloid leukemia (AML) activities in vitro and in vivo. J Med Chem. 2012 Apr 26;55(8):3852-66.

SKLB4771物理化学性质

• 分子式: C₂₅H₂₇N₇O₃S₂
• 分子量: 537.65700
• 精确质量: 537.16200
• PSA: 167.93000
• LogP: 4.76990
• InChIKey: LKXFSTAQMOENSC-UHFFFAOYSA-N
• SMILES: Cc1ccc(NC(=O)Nc2nnc(Sc3ncnc4cc(OCCCN5CCOCC5)ccc34)s2)cc1
• 外观性状: white solid
• 储存条件: -20℃

SKLB4771靶点实验

查看更多实验

实验名称：Cellular viability qHTS for adrenocortical cancer (ACC) cell line SW-13 来源：NCGC 靶标：N/A External Id：ACC-ATC-p1-SW13-72hr

实验名称：Cellular viability qHTS for adrenocortical cancer (ACC) cell line NCI-H295R 来源：NCGC 靶标：N/A External Id：ACC-ATC-p1-H295R-72hr

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

实验名称：Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase... 来源：NCGC External Id：GPx1-biochemical-p4-p7

实验名称：Inhibition of human FLT3 来源：ChEMBL 靶标：Receptor-type tyrosine-protein kinase FLT3 External Id：CHEMBL2050053

实验名称：Antitumor activity against human MV4-11 cells xenografted in NOD-SCID mouse assessed ... 来源：ChEMBL 靶标：MV4-11 External Id：CHEMBL2049296

实验名称：Diffuse intrinsic pontine glioma (SU-DIPG-XVII) cell line screen of MIPE5.0 library: ... 来源：15316 靶标：N/A External Id：s-dipg-DIPG17_CTG48h_mipe5_0-1

实验名称：Toxicity in NOD-SCID mouse bearing human MV4-11 cells assessed as signs of toxicity a... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2049297

实验名称：Cytotoxicity against FLT3-dependent human MV4-11 cells after 72 hrs by MTT assay 来源：ChEMBL 靶标：MV4-11 External Id：CHEMBL2050054

共36条，当前第1页，共4页

1

2

3

4

SKLB4771英文别名

• 1-(5-(7-(3-morpholinopropoxy)quinazolin-4-ylthio)-1,3,4-thiadiazol-2-yl)-3-p-tolylurea
• FLT3-IN-1
• SKLB4771