FEMA 4809

• 常用名: FEMA 4809
• 英文名: FEMA 4809
• CAS号: 1374760-95-8
• 分子量: 327.40
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₁₇N₃O₂S
• 熔点: N/A
• 闪点: N/A

FEMA 4809用途

FEMA 4809是一种TRPM8受体激动剂(EC50=0.2 nM),用作冷却剂。TRPM8是负责冷感知的离子通道【1】。

FEMA 4809名称

• 英文名: FEMA 4809

FEMA 4809生物活性

• 描述: FEMA 4809是一种TRPM8受体激动剂(EC50=0.2 nM),用作冷却剂。TRPM8是负责冷感知的离子通道【1】。
• 相关类别:
  信号通路 >> 跨膜转运 >> TRP频道
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Alain Noncovich, et al. Discovery and development of a novel class of phenoxyacetyl amides as highly potent TRPM8 agonists for use as cooling agents. Bioorg Med Chem Lett. 2017 Aug 15;27(16):3931-3938.

FEMA 4809物理化学性质

• 分子式: C₁₇H₁₇N₃O₂S
• 分子量: 327.40
• InChIKey: QGDQESUNCJQMSA-UHFFFAOYSA-N
• SMILES: Cc1ccc(OCC(=O)N(Cc2cccs2)c2ccn[nH]2)cc1

FEMA 4809靶点实验

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实验名称：Potency index, ratio of WS-3 EC50 to compound EC50 for human TRPM8 receptor 来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily M member 8 External Id：CHEMBL4056646

实验名称：Thermodynamic solubility of the compound in pH 7.1 phosphoric buffer 来源：ChEMBL 靶标：N/A External Id：CHEMBL4056647

实验名称：Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in int... 来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily M member 8 External Id：CHEMBL4056645

实验名称：Induction of off-taste response in rained human subjects during cooling sensation stu... 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL4056654

实验名称：In vivo agonist activity at human TRPM8 in trained human subjects assessed as time du... 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL4056655

实验名称：Permeability of the compound assessed as drug transport by PAMPA 来源：ChEMBL 靶标：N/A External Id：CHEMBL4056652

实验名称：In vivo agonist activity at human TRPM8 in trained human subjects assessed as concent... 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL4056653

实验名称：Effective permeability of the compound by PAMPA 来源：ChEMBL 靶标：N/A External Id：CHEMBL4056651

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