Fosciclopirox

• 常用名: Fosciclopirox
• 英文名: Fosciclopirox
• CAS号: 1380539-06-9
• 分子量: 317.27
• 密度: 1.4±0.1 g/cm3
• 沸点: 484.8±55.0 °C at 760 mmHg
• 分子式: C₁₃H₂₀NO₆P
• 熔点: N/A
• 闪点: 247.0±31.5 °C

Fosciclopirox用途

福昔洛韦通过靶向γ-分泌酶复合物抑制尿路上皮癌的生长。福西氯匹罗可选择性地将活性代谢物环氯匹罗(CPX)输送至整个泌尿道[1][2]。Ciclopirox在许多实体和血液系统恶性肿瘤中具有抗癌活性。

Fosciclopirox名称

• 英文名: [(6-Cyclohexyl-4-methyl-2-oxo-1(2H)-pyridinyl)oxy]methyl dihydrogen phosphate

Fosciclopirox生物活性

• 描述: 福昔洛韦通过靶向γ-分泌酶复合物抑制尿路上皮癌的生长。福西氯匹罗可选择性地将活性代谢物环氯匹罗(CPX)输送至整个泌尿道[1][2]。Ciclopirox在许多实体和血液系统恶性肿瘤中具有抗癌活性。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Weir SJ, Dandawate P, Standing D, Bhattacharyya S, Ramamoorthy P, Rangarajan P, Wood R, Brinker AE, Woolbright BL, Tanol M, Ham T, McCulloch W, Dalton M, Reed GA, Baltezor MJ, Jensen RA, Taylor JA 3rd, Anant S. Fosciclopirox suppresses growth of high-grade urothelial cancer by targeting the γ-secretase complex. Cell Death Dis. 2021 May 31;12(6):562.

  [2]. Weir SJ, Wood R, Schorno K, Brinker AE, Ramamoorthy P, Heppert K, Rajewski L, Tanol M, Ham T, McKenna MJ, McCulloch W, Dalton M, Reed GA, Jensen RA, Baltezor MJ, Anant S, Taylor JA 3rd. Preclinical Pharmacokinetics of Fosciclopirox, a Novel Treatment of Urothelial Cancers, in Rats and Dogs. J Pharmacol Exp Ther. 2019 Aug;370(2):148-159.

Fosciclopirox物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 484.8±55.0 °C at 760 mmHg
• 分子式: C₁₃H₂₀NO₆P
• 分子量: 317.27
• 闪点: 247.0±31.5 °C
• 精确质量: 317.102814
• LogP: 1.50
• 蒸汽压: 0.0±2.6 mmHg at 25°C
• 折射率: 1.566

Fosciclopirox英文别名

• 2(1H)-Pyridinone, 6-cyclohexyl-4-methyl-1-[(phosphonooxy)methoxy]-
• [(6-Cyclohexyl-4-methyl-2-oxo-1(2H)-pyridinyl)oxy]methyl dihydrogen phosphate