Fosciclopirox

Modify Date: 2024-01-14 12:00:56

Fosciclopirox structure	Common Name	Fosciclopirox
	CAS Number	1380539-06-9	Molecular Weight	317.27
	Density	1.4±0.1 g/cm3	Boiling Point	484.8±55.0 °C at 760 mmHg
	Molecular Formula	C₁₃H₂₀NO₆P	Melting Point	N/A
	MSDS	N/A	Flash Point	247.0±31.5 °C

Use of Fosciclopirox

Fosciclopirox suppresses growth of urothelial cancer by targeting the γ-secretase complex. Fosciclopirox selectively delivers the active metabolite, Ciclopirox (CPX), to the entire urinary tract[1][2]. Ciclopirox has anticancer activity in a number of solid and hematologic malignancies.

Name	[(6-Cyclohexyl-4-methyl-2-oxo-1(2H)-pyridinyl)oxy]methyl dihydrogen phosphate
Synonym	More Synonyms

Description	Fosciclopirox suppresses growth of urothelial cancer by targeting the γ-secretase complex. Fosciclopirox selectively delivers the active metabolite, Ciclopirox (CPX), to the entire urinary tract[1][2]. Ciclopirox has anticancer activity in a number of solid and hematologic malignancies.
Related Catalog	Research Areas >> Cancer Research Areas >> Metabolic Disease
References	[1]. Weir SJ, Dandawate P, Standing D, Bhattacharyya S, Ramamoorthy P, Rangarajan P, Wood R, Brinker AE, Woolbright BL, Tanol M, Ham T, McCulloch W, Dalton M, Reed GA, Baltezor MJ, Jensen RA, Taylor JA 3rd, Anant S. Fosciclopirox suppresses growth of high-grade urothelial cancer by targeting the γ-secretase complex. Cell Death Dis. 2021 May 31;12(6):562. [2]. Weir SJ, Wood R, Schorno K, Brinker AE, Ramamoorthy P, Heppert K, Rajewski L, Tanol M, Ham T, McKenna MJ, McCulloch W, Dalton M, Reed GA, Jensen RA, Baltezor MJ, Anant S, Taylor JA 3rd. Preclinical Pharmacokinetics of Fosciclopirox, a Novel Treatment of Urothelial Cancers, in Rats and Dogs. J Pharmacol Exp Ther. 2019 Aug;370(2):148-159.

Description

Related Catalog

Research Areas >> Cancer

Research Areas >> Metabolic Disease

References

[1]. Weir SJ, Dandawate P, Standing D, Bhattacharyya S, Ramamoorthy P, Rangarajan P, Wood R, Brinker AE, Woolbright BL, Tanol M, Ham T, McCulloch W, Dalton M, Reed GA, Baltezor MJ, Jensen RA, Taylor JA 3rd, Anant S. Fosciclopirox suppresses growth of high-grade urothelial cancer by targeting the γ-secretase complex. Cell Death Dis. 2021 May 31;12(6):562.

[2]. Weir SJ, Wood R, Schorno K, Brinker AE, Ramamoorthy P, Heppert K, Rajewski L, Tanol M, Ham T, McKenna MJ, McCulloch W, Dalton M, Reed GA, Jensen RA, Baltezor MJ, Anant S, Taylor JA 3rd. Preclinical Pharmacokinetics of Fosciclopirox, a Novel Treatment of Urothelial Cancers, in Rats and Dogs. J Pharmacol Exp Ther. 2019 Aug;370(2):148-159.

Density	1.4±0.1 g/cm3
Boiling Point	484.8±55.0 °C at 760 mmHg
Molecular Formula	C₁₃H₂₀NO₆P
Molecular Weight	317.27
Flash Point	247.0±31.5 °C
Exact Mass	317.102814
LogP	1.50
Vapour Pressure	0.0±2.6 mmHg at 25°C
Index of Refraction	1.566

2(1H)-Pyridinone, 6-cyclohexyl-4-methyl-1-[(phosphonooxy)methoxy]-

[(6-Cyclohexyl-4-methyl-2-oxo-1(2H)-pyridinyl)oxy]methyl dihydrogen phosphate

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Fosciclopirox
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Fosciclopirox
Price: ￥550.0/100mg ￥950.0/250mg ￥1800.0/1g ￥220.0/10ml
Purity: 98.0%
Delivery: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Fosciclopirox
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

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Fosciclopirox

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