(R,R)-THC

• 常用名: (R,R)-THC
• 英文名: (R,R)-THC
• CAS号: 138090-06-9
• 分子量: 320.42
• 密度: 1.21g/cm3
• 沸点: 519ºC at 760mmHg
• 分子式: C₂₂H₂₄O₂
• 熔点: N/A
• 闪点: 239.5ºC

(R,R)-THC用途

(R,R)-THC是ERα激动剂和ERβ拮抗剂,ERα和ERβ的Kis分别为9.0 nM和3.6 nM。(R,R)-THC对ERβ的相对结合亲和力高于ERα,分别为25和3.6【1】。

(R,R)-THC名称

• 英文名: cis-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol

(R,R)-THC生物活性

• 描述: (R,R)-THC是ERα激动剂和ERβ拮抗剂,ERα和ERβ的Kis分别为9.0 nM和3.6 nM。(R,R)-THC对ERβ的相对结合亲和力高于ERα,分别为25和3.6【1】。
• 相关类别:
  信号通路 >> 其他 >> 雌激素受体/ERR
  研究领域 >> 代谢疾病
• 靶点实验:

  ERα:9.0 nM (Ki)

  ERβ:3.6 nM (Ki)

• 参考文献:

  [1]. Sun J, et al. Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-alpha or estrogen receptor-beta. Endocrinology. 1999;140(2):800-804.

(R,R)-THC物理化学性质

• 密度: 1.21g/cm3
• 沸点: 519ºC at 760mmHg
• 分子式: C₂₂H₂₄O₂
• 分子量: 320.42
• 闪点: 239.5ºC
• 精确质量: 320.17800
• PSA: 40.46000
• LogP: 5.17320
• 蒸汽压: 2.17E-11mmHg at 25°C
• 折射率: 1.65

(R,R)-THC安全信息

• 安全声明 (欧洲): S22

(R,R)-THC靶点实验

查看更多实验

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

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实验名称：Relative binding affinity for human Estrogen receptor beta compared to estradiol (E2) 来源：ChEMBL 靶标：Estrogen receptor beta External Id：CHEMBL677228

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_SinglePoint... 来源：Broad Institute 靶标：N/A External Id：2084-01_Activator_SinglePoint_HTS_Activity

实验名称：Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberc... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：GDH-TPI_INH_ABS_1536_1X%INH CSRUN

实验名称：qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity 来源：NCGC External Id：HERG01

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(R,R)-THC英文别名

• (R,R)-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol