Nomega-Allyl-L-arginine hydrochloride

• 常用名: Nomega-Allyl-L-arginine hydrochloride
• 英文名: Nomega-Allyl-L-arginine hydrochloride
• CAS号: 139461-37-3
• 分子量: 214.26500
• 密度: 1.23g/cm3
• 沸点: 394.4ºC at 760mmHg
• 分子式: C₉H₁₈N₄O₂
• 熔点: N/A
• 闪点: 192.3ºC

Nomega-Allyl-L-arginine hydrochloride用途

Nω-烯丙基-L-精氨酸是牛脑一氧化氮合酶(nNOS)的竞争性可逆抑制剂。Nω-烯丙基-L-精氨酸能以时间依赖性方式使NNO失活。Nω-烯丙基-L-精氨酸也是一种底物,产生L-精氨酸、丙烯醛和H2O[1][2]。

Nomega-Allyl-L-arginine hydrochloride名称

• 英文名: (2S)-2-amino-5-[(N'-prop-2-enylcarbamimidoyl)amino]pentanoic acid

Nomega-Allyl-L-arginine hydrochloride生物活性

• 描述: Nω-烯丙基-L-精氨酸是牛脑一氧化氮合酶(nNOS)的竞争性可逆抑制剂。Nω-烯丙基-L-精氨酸能以时间依赖性方式使NNO失活。Nω-烯丙基-L-精氨酸也是一种底物,产生L-精氨酸、丙烯醛和H2O[1][2]。
• 相关类别:
  信号通路 >> 免疫及炎症 >> 一氧化氮合酶
  研究领域 >> 神经疾病
• 靶点实验:

  nitric oxide synthase (nNOS)[1]

• 参考文献:

  [1]. Zhang HQ, et, al. Mechanism of Inactivation of Neuronal Nitric Oxide Synthase by Nω-Allyl-l-Arginine. J. Am. Chem. Soc. 1997, 119, 45, 10888-10902.

  [2]. Hah JM, et, al. Deuterium isotope effects and product studies for the oxidation of N(omega)-allyl-L-arginine and N(omega)-allyl-N(omega)-hydroxy-L-arginine by neuronal nitric oxide synthase. Bioorg Med Chem. 2000 Aug;8(8):1931-6.

Nomega-Allyl-L-arginine hydrochloride物理化学性质

• 密度: 1.23g/cm3
• 沸点: 394.4ºC at 760mmHg
• 分子式: C₉H₁₈N₄O₂
• 分子量: 214.26500
• 闪点: 192.3ºC
• 精确质量: 214.14300
• PSA: 111.23000
• LogP: 1.06030
• 蒸汽压: 2.54E-07mmHg at 25°C
• 折射率: 1.549

Nomega-Allyl-L-arginine hydrochloride靶点实验

查看更多实验

实验名称：Inhibition of human recombinant eNOS at 1 uM 来源：ChEMBL 靶标：Nitric oxide synthase, endothelial External Id：CHEMBL1020501

实验名称：Inhibition of human recombinant iNOS at 100 uM 来源：ChEMBL 靶标：Nitric oxide synthase, inducible External Id：CHEMBL1020502

实验名称：Inhibition of human recombinant iNOS at 1 uM 来源：ChEMBL 靶标：Nitric oxide synthase, inducible External Id：CHEMBL1020499

实验名称：Inhibition of human recombinant nNOS at 1 uM 来源：ChEMBL 靶标：Nitric oxide synthase, brain External Id：CHEMBL1020500

实验名称：In Vitro hDDAH-1 Assay from Article 10.3109/14756366.2011.573480: "Designing modulato... 来源：BindingDB 靶标：N/A External Id：BindingDB_8172_1

实验名称：Inhibition of human recombinant nNOS at 100 uM 来源：ChEMBL 靶标：Nitric oxide synthase, brain External Id：CHEMBL1020497

实验名称：Inhibition of human recombinant eNOS at 100 uM 来源：ChEMBL 靶标：Nitric oxide synthase, endothelial External Id：CHEMBL1020498

实验名称：Compound was tested for the inhibition of inducible murine macrophage expressed as in... 来源：ChEMBL 靶标：N/A External Id：CHEMBL754644

实验名称：Selectivity index which is the ratio of the Ki or IC50 values of recombinant bovine e... 来源：ChEMBL 靶标：N/A External Id：CHEMBL679292

实验名称：Selectivity index which is the ratio of the Ki or IC50 values of recombinant bovine E... 来源：ChEMBL 靶标：N/A External Id：CHEMBL679291

共14条，当前第1页，共2页

1

2

Nomega-Allyl-L-arginine hydrochloride英文别名

• L-Ornithine,N5-(imino(2-propenylamino)methyl)
• N(G)-Allylarginine
• NG-allyl-L-arginine
• Nw-allyl-L-arginine
• ARV