M-110

更新时间：2026-07-15 12:48:31

M-110用途

M-110是Pim激酶抑制剂,抑制前列腺癌细胞系增殖IC50为0.6-0.9uM。

描述	M-110是Pim激酶抑制剂,抑制前列腺癌细胞系增殖IC50为0.6-0.9uM。
相关类别	信号通路 >> JAK/STAT信号通路 >> 皮姆研究领域 >> 癌症
参考文献	[1]. He Y, et al. Schisantherin A suppresses osteoclast formation and wear particle-induced osteolysis via modulating RANKL signaling pathways. Biochem Biophys Res Commun. 2014 Jul 4;449(3):344-50. [2]. Zhou E, et al. Schisantherin A protects lipopolysaccharide-induced acute respiratory distress syndrome in mice through inhibiting NF-κB and MAPKs signaling pathways. Int Immunopharmacol. 2014 Sep;22(1):133-40. [3]. Sa F, et al. Discovery of novel anti-parkinsonian effect of schisantherin A in in vitro and in vivo. Neurosci Lett. 2015 Apr 23;593:7-12. [4]. Zhang LQ, et al. Schisantherin A protects against 6-OHDA-induced dopaminergic neuron damage in zebrafish and cytotoxicity in SH-SY5Y cells through the ROS/NO and AKT/GSK3β pathways. J Ethnopharmacol. 2015 Apr 29. pii: S0378-8741(15)00306-2.

描述

M-110是Pim激酶抑制剂,抑制前列腺癌细胞系增殖IC50为0.6-0.9uM。

相关类别

信号通路 >> JAK/STAT信号通路 >> 皮姆

研究领域 >> 癌症

参考文献

密度	1.3±0.1 g/cm3
分子式	C₂₂H₂₈ClN₅O₃
分子量	445.94
精确质量	445.188080
LogP	4.08
InChIKey	FXXCNYVQIONABS-LGUFXXKBSA-N
SMILES	CCC(=NNC(=O)c1ccnc(NCCCN2CCOCC2)c1)c1ccc(Cl)cc1O
折射率	1.623
储存条件	2-8°C

危险品运输编码	NONH for all modes of transport

实验名称：HTS to identify compounds that affect the blood-brain barrier permeability in vitro
来源：26908
靶标：N/A
External Id：HTS97080

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4-Pyridinecarboxylic acid, 2-[[3-(4-morpholinyl)propyl]amino]-, 2-[(1E)-1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide

MFCD28053523

N'-[(1E)-1-(4-Chloro-2-hydroxyphenyl)propylidene]-2-{[3-(4-morpholinyl)propyl]amino}isonicotinohydrazide