DNMT3A-IN-1

• 常用名: DNMT3A-IN-1
• 英文名: DNMT3A-IN-1
• CAS号: 1403598-56-0
• 分子量: 546.66
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₀H₃₈N₆O₄
• 熔点: N/A
• 闪点: N/A

DNMT3A-IN-1用途

DNMT3A-IN-1是一种有效的选择性DNMT3A抑制剂。DNMT3A-IN-1显示出针对DNMT3A的抑制剂活性,kI值范围为9.16-18.85μM(AdoMet)和11.37-23.34μM(poly-dI-dC)[1]。

DNMT3A-IN-1名称

• 英文名: DNMT3A-IN-1

DNMT3A-IN-1生物活性

• 描述: DNMT3A-IN-1是一种有效的选择性DNMT3A抑制剂。DNMT3A-IN-1显示出针对DNMT3A的抑制剂活性,kI值范围为9.16-18.85μM(AdoMet)和11.37-23.34μM(poly-dI-dC)[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 表观遗传学 >> DNA甲基转移酶
• 靶点实验:

  DNMT3A

• 参考文献:

  [1]. Huang S, et al. A novel class of selective non-nucleoside inhibitors of human DNA methyltransferase 3A. Bioorg Med Chem Lett. 2021; 40:127908.

DNMT3A-IN-1物理化学性质

• 分子式: C₃₀H₃₈N₆O₄
• 分子量: 546.66
• InChIKey: JPXAIORZGBCHIB-UHFFFAOYSA-N
• SMILES: COc1ccc(C2=NN(C3CCCCCC3)C(=O)C2(C)C)cc1OCCCCOc1ccc(-c2nn[nH]n2)cc1

DNMT3A-IN-1靶点实验

查看更多实验

实验名称：Antitrypanosomal activity against Trypanosoma brucei brucei 427 bloodstream forms aft... 来源：ChEMBL 靶标：Trypanosoma brucei brucei External Id：CHEMBL4369188

实验名称：Inhibition of wild type full length recombinant human DNMT3A expressed in NiCo21(DE3)... 来源：ChEMBL 靶标：DNA (cytosine-5)-methyltransferase 3-like External Id：CHEMBL5125868

实验名称：Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL4296184

实验名称：Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL4296186

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CA... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4296185

实验名称：AntiTrypanosoma brucei activity T. b. brucei IC50 (uM) 来源：ChEMBL 靶标：Trypanosoma brucei External Id：CHEMBL3832786

实验名称：Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 4... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL4369192

实验名称：Antitrypanosomal activity against Trypanosoma brucei brucei 427 bloodstream forms aft... 来源：ChEMBL 靶标：Trypanosoma brucei brucei External Id：CHEMBL4369191

实验名称：Antitrypanosomal activity against Trypanosoma brucei brucei 427 bloodstream forms ass... 来源：ChEMBL 靶标：Trypanosoma brucei brucei External Id：CHEMBL4369190

实验名称：Compound was evaluated for the inhibition of human FECH at 10uM 来源：ChEMBL 靶标：Ferrochelatase, mitochondrial External Id：CHEMBL3987222

共44条，当前第1页，共5页

1

2

3

4

5