Tuberculosis inhibitor 8

• 常用名: Tuberculosis inhibitor 8
• 英文名: Tuberculosis inhibitor 8
• CAS号: 141353-07-3
• 分子量: 362.40
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₁₉FN₄O
• 熔点: N/A
• 闪点: N/A

Tuberculosis inhibitor 8用途

Tuberculosis inhibitor 8 (compound 3b) 是一种 3-甲氧基-2-苯基咪唑并[1,2-b]哒嗪衍生物,对结核分枝杆菌 (MIC90 为 0.69 μM) 和海洋分枝杆菌 (MIC90 为 0.69 μM) 表现出高度活性。

Tuberculosis inhibitor 8名称

• 英文名: Tuberculosis inhibitor 8

Tuberculosis inhibitor 8生物活性

• 描述: Tuberculosis inhibitor 8 (compound 3b) 是一种 3-甲氧基-2-苯基咪唑并[1,2-b]哒嗪衍生物,对结核分枝杆菌 (MIC90 为 0.69 μM) 和海洋分枝杆菌 (MIC90 为 0.69 μM) 表现出高度活性。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Kyle D Farrell, et al. 3-Methoxy-2-phenylimidazo[1,2-b]pyridazines highly active against Mycobacterium tuberculosis and Mycobacterium marinum. Eur J Med Chem. 2023 Nov 5;259:115637.

Tuberculosis inhibitor 8物理化学性质

• 分子式: C₂₁H₁₉FN₄O
• 分子量: 362.40
• InChIKey: QAMWJWRMJYBJMS-UHFFFAOYSA-N
• SMILES: COc1c(-c2ccccc2F)nc2ccc(N(C)Cc3ccccc3)nn12

Tuberculosis inhibitor 8靶点实验

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实验名称：Octanol-water distribution coefficient, logD of the compound at pH 7.4 by HPLC analys... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5627293

实验名称：Kinetic solubility of compound in DMSO at pH 2 incubated for 30 mins by laser nephelo... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5627294

实验名称：Kinetic solubility of compound in DMSO at pH 6.5 incubated for 30 mins by laser nephe... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5627295

实验名称：Metabolic stability in mouse liver microsomes assessed as half life incubated for 60 ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5627296

实验名称：Metabolic stability in mouse liver microsomes assessed as intrinsic clearance incubat... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5627297

实验名称：Antimycobacterial activity against Mycobacterium tuberculosis H37Ra infected in mouse... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL5627300

实验名称：Antimycobacterial activity against Mycobacterium tuberculosis H37Ra assessed as inhib... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL5627291

实验名称：Antimycobacterial activity against Mycobacterium marinum assessed as inhibition of ba... 来源：ChEMBL 靶标：Mycobacterium marinum External Id：CHEMBL5627292

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